富血小板纤维蛋白与胶原膜修复牙龈缺损创面的能力

发布时间：2018-01-23 12:48

本文关键词： 牙龈软组织损伤伤口愈合组织工程生物材料材料相容性富血小板纤维蛋白脱细胞真皮基质牙龈软组织缺损创面愈合　出处：《中国组织工程研究》2016年16期 　论文类型：期刊论文

【摘要】：背景:前期实验中发现富血小板纤维蛋白具有良好的诱导牙龈软组织修复再生的能力。目的:观察富血小板纤维蛋白膜与胶原膜对牙龈软组织愈合的影响,评价富血小板纤维蛋白膜诱导牙龈软组织缺损修复再生的能力。方法:选因各种原因需要拔除前磨牙或磨牙同期进行位点保存的患者22例(前磨牙2颗,磨牙20颗),随机分为2组,22个软组织缺损区域,拔牙窝内植入Bio-Oss,表面覆盖富血小板纤维蛋白膜或海奥胶原膜。通过追踪植入Bio-Oss后牙龈创面的愈合时间和植入Bio-Oss后1,2周的创面愈合率,评价富血小板纤维蛋白促进牙龈组织愈合的能力。结果与结论:①富血小板纤维蛋白组愈合时间为(12.17±2.25)d,胶原膜组愈合时间为(17.30±2.58)d;植入Bio-Oss后1,2周富血小板纤维蛋白组愈合率明显高于胶原膜组。②结果说明,相同时间节点时富血小板纤维蛋白促进牙龈软组织的愈合能力明显优于胶原膜,达到相同愈合状态时富血小板纤维蛋白组所需时间明显短于胶原膜组。
[Abstract]:Background: it was found that platelet-rich fibrin has a good ability to induce the repair and regeneration of gingival soft tissue. Objective: to observe the effect of platelet-rich fibrin membrane and collagen membrane on the healing of soft tissue of gingival. To evaluate the ability of platelet-rich fibrin membrane to repair and regenerate soft tissue defect of gingival. Methods: 22 patients (2 premolars) who needed to remove premolars or preserve their sites simultaneously for various reasons were selected. Twenty molars were randomly divided into 2 groups with 22 soft tissue defect areas and Bio-Oss implanted in the extraction fossa. The surface was covered with platelet-rich fibrin membrane or sea auricular collagen membrane. The healing time of gingival wound after Bio-Oss implantation and the wound healing rate of 1 ~ 2 weeks after Bio-Oss implantation were tracked. Results and conclusion the healing time of platelet-rich fibrin group was 12.17 卤2.25 days. The healing time of collagen membrane group was 17.30 卤2.58 days. The healing rate of platelet-rich fibrin group was significantly higher than that of collagen membrane group at 1 and 2 weeks after Bio-Oss implantation. The ability of platelet rich fibrin to promote the healing of gingival soft tissue at the same time node was significantly better than that of collagen membrane, and the time of platelet rich fibrin group was significantly shorter than that of collagen membrane group when it reached the same healing state.
【作者单位】：解放军成都军区机关医院口腔科;重庆拜博口腔医院管理有限公司九龙坡口腔医院;遂宁市第一人民医院口腔科;
【基金】：成都军区“十二五”科研面上项目(C14050)~~
【分类号】：R783.6
【正文快照】： 0 引言Introduction 种植牙被誉为人类的“第三副牙”[1],已被广泛应用于牙列缺损或牙列缺失患者的修复,随着材料学和种植体表面处理技术的不断发展,良好的骨整合不再是判断种植成功的唯一标准,种植义齿修复的美学效果和颈部良好的生物封闭也是其效果评价的重要指标[2]。牙

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