碳酸氢钠联合氟康唑治疗糖尿病患者口腔真菌感染的疗效评价

发布时间：2018-01-29 07:43

本文关键词： 碳酸氢钠氟康唑糖尿病口腔真菌感染　出处：《中华医院感染学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的探究碳酸氢钠联合氟康唑治疗糖尿病患者口腔真菌感染的疗效评价。方法对医院2013年2月-2016年2月收治的83例糖尿病合并口腔真菌感染患者作为研究对象,分析感染真菌类型分布及构成;按照随机双盲法将患者分为观察组42例及对照组41例;观察组使用碳酸氢钠联合氟康唑治疗,而对照组仅使用氟康唑治疗;观察两组的治疗效果。结果对83例糖尿病合并口腔真菌感染患者行口腔真菌涂片检查共发现致病菌92株,其中白假丝酵母菌最多占51.09%;两组患者在治疗前口腔PH及白斑面积相差较小,经过不同治疗后,观察组口腔PH及白斑面积分别为(7.52±0.24)及(2.21±1.14)mm~2,均明显优于对照组水平,差异有统计学意义(P0.05);观察组治愈率为50.00%,总有效率为92.86%,显著高于对照组水平,差异有统计学意义(P0.05)。结论糖尿病患者合并口腔真菌感染时,以白假丝酵母菌为主要致病菌,使用碳酸氢钠联合氟康唑可显著改善口腔环境,提高治疗效果,值得临床推广使用。
[Abstract]:Objective to explore the evaluation of sodium bicarbonate combined with fluconazole in the treatment of diabetic patients curative effect of oral fungal infection. Methods the hospital in February 2013 -2016 year in February 83 cases of diabetes mellitus complicated with oral fungal infection patients as the research object, analysis of fungal infection type distribution and composition; according to the randomized double blind method were divided into observation group and control group in 42 cases and 41 cases of observation; the use of sodium bicarbonate combined with fluconazole in the treatment group, while the control group only use of fluconazole in the treatment of the therapeutic effect of the two groups; observation. Results of 83 cases of diabetes mellitus complicated with fungal infection in patients with oral cavity fungal smear examination of 92 strains of pathogenic bacteria were found, of which Candida albicans accounted for 51.09%; two groups of patients before treatment of oral leukoplakia and PH the area is small, after different treatment, the observation group oral PH and white area respectively (7.52 + 0.24) and (2.21 + 1.14) mm~2, were significantly better than the control group Level, the difference was statistically significant (P0.05); the cure rate of observation group was 50%, the total effective rate was 92.86%, significantly higher than that of the control group, the difference was statistically significant (P0.05). Conclusion diabetic patients with oral fungal infection, Candida albicans is the main pathogenic bacteria, using sodium bicarbonate combined with fluconazole can significantly improve the oral the environment, improve the therapeutic effect, is worthy of clinical use.

【作者单位】：平煤神马医疗集团总医院口腔科;
【基金】：河南省医学科技攻关计划基金资助项目(201404H007)
【分类号】：R587.1;R781.5
【正文快照】： 糖尿病是危害现代人群最常见的疾病之一,有文献报道[1-2],全球范围内所有年龄组的糖尿病患病率进行评估,糖尿病的患病率在近25年内将由2.6%升高到4.9%。张华章[3]等研究发现近些年糖尿病患者合并各系统感染的案例不断增高,考虑此现象与糖尿病患者长期血糖过高,较大的血浆胶体

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