Nav1.6在口腔黏膜白斑及口腔鳞癌中的表达

发布时间：2018-02-24 11:42

本文关键词： Nav. 口腔黏膜白斑口腔鳞状细胞癌　出处：《实用口腔医学杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的:探讨钠离子通道Nav1.6在口腔黏膜白斑及口腔鳞癌中的表达及意义。方法:采用免疫组化SP法及Western blot法检测Nav1.6在口腔正常组织(21例)、白斑(32例)及口腔鳞癌组织(63例)中的表达情况。结果:免疫组化检测,Nav1.6在正常组、口腔白斑组以及癌症组中的阳性表达率分别为6.25%、40%、76.74%;Nav1.6的表达与口腔鳞癌的病理分期有关。Western blot检测,正常组、口腔白斑组、癌症组中Nav1.6的蛋白表达量分别为:0.469±0.015、0.545±0.016、0.848±0.020(P0.05)。结论:Nav1.6在口腔黏膜癌前病变及口腔鳞状细胞癌的发生和发展中可能起到了一定的作用。
[Abstract]:Objective: to investigate the expression and significance of sodium channel Nav1.6 in oral leukoplakia and oral squamous cell carcinoma. Methods: immunohistochemical SP method and Western blot method were used to detect Nav1.6 in 21 cases of normal oral tissue and 32 cases of leukoplakia) and oral squamous cell carcinoma (OSCC). Results: immunohistochemical method was used to detect the expression of Nav1.6 in the normal group. The positive expression rates of Nav1.6 in oral leukoplakia group and cancer group were 6.25% and 76.74%, respectively. The expression of Nav1.6 was related to the pathological stage of oral squamous cell carcinoma. The expression of Nav1.6 protein in cancer group was 0. 469 卤0. 015 + 0. 545 卤0. 016 卤0. 848 卤0. 020 P0. 05 respectively. Conclusion: n Nav1.6 may play an important role in the occurrence and development of oral squamous cell carcinoma and precancerous lesion of oral mucosa.
【作者单位】：安徽医科大学口腔医学院·口腔医院口腔预防教研室安徽省口腔疾病研究中心实验室;
【基金】：安徽省自然科学基金(编号:1508085MH187)
【分类号】：R739.8

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