纳米氟磷灰石聚醚醚酮种植体骨界面的定量分析

发布时间：2018-02-26 08:15

本文关键词： 纳米氟磷灰石聚醚醚酮喷砂骨形态计量学　出处：《上海口腔医学》2014年02期 　论文类型：期刊论文

【摘要】：目的:通过犬动物实验,检测喷砂处理螺纹柱状纳米氟磷灰石聚醚醚酮材料(nFA/PEEK)的生物相容性和成骨性能。方法:将喷砂和非喷砂nFA/PEEK各10颗,延期植入6只犬下颌前磨牙区,术后8周和12周末各随机处死3只,种植体骨标本行同步辐射扫描后,制作非脱钙种植骨组织切片,四环素荧光标记测定动态参数骨结合率(BIC)和矿化沉积率(MAR)。苦味酸品红染色测定骨的静态参数。采用SPSS18.0软件包对数据进行统计学分析。结果:同步辐射扫描8周,种植体骨床界面呈现连续接触,新生骨组织长入螺纹凹陷处;12周均基本形成骨结合,喷砂组新骨形成和成熟更快。8周末的BIC(63.34%)和MAR(1.51μm/d)均显著高于(P0.05)未喷砂组种植体(22.97%,1.34μm/d);12周末喷砂组的BIC(75.49%)显著高于(P0.05)未喷砂组(55.35%),但MAR(1.28μm/d对1.27μm/d)无显著差异。骨静态学参数喷砂组骨体积分数和骨小梁数量显著高于非喷砂组,但骨小梁间隔显著低于非喷砂组(P0.05),表明喷砂组更有利于骨量的增加,但骨小梁厚度无显著差异。结论:本研究表明,喷砂处理nFA/PEEK种植体具有良好的生物相容性,与其骨床结合紧密。
[Abstract]:Objective: to investigate the biocompatibility and osteogenic properties of sand blast treated columnar fluoroapatite polyether ether ketone (PEEK). Methods: 10 nFA/PEEK and 10 nFA/PEEK were implanted into the mandibular premolars of 6 dogs. After 8 weeks and 12 weeks of operation, 3 implants were randomly killed. After synchrotron radiation scanning, non-decalcified bone tissue sections were made. The dynamic parameter bone binding rate and mineralized deposition rate were determined by tetracycline fluorescence labeling. The static parameters of bone were determined by picric acid fuchsin staining. The data were analyzed statistically by SPSS18.0 software package. Results: synchrotron radiation scanning was performed for 8 weeks. The interface of implant bone bed was in continuous contact, and the bone union was basically formed at 12 weeks after the new bone tissue was inserted into the thread depression. The new bone formation and maturation in the sand blasting group were significantly higher than those in the sand blasting group at the end of the 8th week (63.34) and MAR(1.51 渭 m / d (P 0.05). The bone static parameters of the sand blasting group were significantly higher than that of the sand blasting group at the 12th weekend (P 0.05), but there was no significant difference between the MAR(1.28 渭 m / d and 1.27 渭 m / d group in bone static parameters. The volume fraction and the number of bone trabeculae were significantly higher than those of non-sand blasting group. But the bone trabecular interval was significantly lower than that in the non-sand blast group (P 0.05), which indicated that the sand blasting group was more favorable for the increase of bone mass, but there was no significant difference in the bone trabecular thickness. Conclusion: this study shows that the nFA/PEEK implants treated by sandblasting have good biocompatibility. Closely bound to its bony bed.
【作者单位】：同济大学口腔医学院口腔生物医学及转化医学实验室;华东理工大学材料学院;
【分类号】：R783.1

【相似文献】