考试压力对大学生唾液中CCL28与sIgA的影响

发布时间：2018-03-01 03:24

本文关键词： 唾液分泌型免疫球蛋白A 黏膜相关上皮趋化因子考试应激　出处：《山东大学学报(医学版)》2014年01期 　论文类型：期刊论文

【摘要】：目的通过检测大学生考试前后唾液中黏膜相关上皮趋化因子(mucosa-associated epithelia chemokine,CCL28/MEC)与分泌型免疫球蛋白A(secretory immunoglobin A,sIgA)含量的变化,探讨考试应激对口腔黏膜免疫功能的影响。方法收集37名大学生(17名大二女生,10名大三男生和10名大三女生,后两者分别设为男生组和女生组)考试前后的非刺激性全唾液,采用酶联免疫吸附试验检测唾液中CCL28与sIgA水平的变化。结果考后37名学生唾液中CCL28与sIgA的吸光度值低于考前水平,差异有统计学意义(P0.05);女生组比男生组的考试前后唾液CCL28水平的变化更显著(P0.05);女生组考试前后唾液中CCL28水平的变化比sIgA更为明显(P0.05),而男生组考试前后唾液中两指标间变化的差异不明显。结论考试应激能促进唾液中sIgA与CCL28水平的升高,女性比男性更容易受考试应激的影响。
[Abstract]:Objective to investigate the changes of mucosa-associated epithelia chemokine CCL28 / MECand secretory immunoglobin IgA in saliva of college students before and after examination. To explore the effect of test stress on oral mucosal immune function. Methods 37 college students, 17 sophomores, 10 junior boys and 10 junior girls, were divided into male group and female group. Enzyme linked immunosorbent assay (Elisa) was used to detect the changes of CCL28 and sIgA in saliva. Results the absorbance values of CCL28 and sIgA in saliva of 37 students were lower than those before examination. The difference was statistically significant (P 0.05), the level of saliva CCL28 in female group was significantly higher than that in male group before and after the examination, and the change of CCL28 level in saliva of female group was more obvious than that of sIgA before and after the examination, while the two indexes in saliva of male group before and after the examination were more obvious than those in female group before and after the examination. Conclusion Test stress can increase the levels of sIgA and CCL28 in saliva. Women are more susceptible to test stress than men.
【作者单位】：山东大学口腔医学院综合科山东省口腔生物医学重点实验室;
【基金】：2011年度国家级大学生创新创业训练计划项目(1110422067)
【分类号】：R781.7

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