胶原层粘连结合蛋白的结构和功能及防治策略

发布时间：2018-03-13 08:11

本文选题：变异链球菌　切入点：胶原层粘连结合蛋白　出处：《国际口腔医学杂志》2015年04期 　论文类型：期刊论文

【摘要】：变异链球菌既与龋病关系密切,亦与感染性心内膜炎和动脉粥样硬化等病变密切相关,其表面的胶原层粘连结合蛋白(Cnm)具有结合胶原蛋白和层粘连蛋白的能力。Cnm蛋白分子中编号152~316基团的165个氨基酸序列跟胶原结合蛋白的胶原结构域高度相似,与金黄色葡萄球菌、粪肠球菌和马链球菌胶原结合蛋白具有高度的同源性。Cnm蛋白存在于变异链球菌中,介导细菌与细胞外基质的结合和在宿主细胞内的侵袭;此外,Cna B和Cbp A蛋白也可能在结合细胞外基质和侵袭宿主细胞方面起着重要的作用。研究者们认为:一方面可将Cnm蛋白作为生物标志物以筛选患者,从而判断是否需要接受预防性治疗;另一方面也可将Cnm蛋白作为治疗变异链球菌感染的目标;但是,目前的研究尚未发现能抑制cnm基因或Cnm蛋白的有效药物,还需进一步研究。有关Cnm蛋白的研究,对于人工干预变异链球菌黏附力、聚集及其生物膜形成,对于龋病和其他全身系统疾病尤其是心内膜炎等疾病的防治具有重要的意义。
[Abstract]:Streptococcus mutans are closely related to both dental caries, infective endocarditis and atherosclerosis. Its surface collagen laminin binding protein (Cnm) has the ability to bind to collagen and laminin. The 165 amino acid sequences of the 152t316group in the Cnm protein are highly similar to the collagen domain of the collagen-binding protein, and are similar to those of Staphylococcus aureus. The collagen-binding proteins of Enterococcus faecalis and Streptococcus equi have high homology. Cnm protein exists in Streptococcus mutans and mediates the binding of bacteria to extracellular matrix and invasion in host cells. In addition, Cbp B and Cbp A proteins may also play an important role in binding extracellular matrix to host cells. The researchers believe that, on the one hand, Cnm proteins can be used as biomarkers to screen patients. In order to determine the need for preventive treatment; on the other hand, the Cnm protein can also be targeted for the treatment of Streptococcus mutans infection. However, no effective drug has been found to inhibit the cnm gene or Cnm protein. The study of Cnm protein is of great significance for the artificial intervention of adhesion, aggregation and biofilm formation of Streptococcus mutans, and for the prevention and treatment of caries and other systemic diseases, especially endocarditis.
【作者单位】：口腔疾病研究国家重点实验室华西口腔医院牙体牙髓病科(四川大学);
【基金】：国家自然科学基金(31000058)
【分类号】：R781.1

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