MMP-14与EMMPRIN在口腔鳞状细胞癌中的表达及临床意义

发布时间：2018-03-14 13:02

  本文选题：口腔鳞状细胞癌　切入点：基质金属蛋白酶-　出处：《空军医学杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的探讨基质金属蛋白酶-14(matrix metalloproteinase 14,MMP-14)和细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer,EMMPRIN)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中的临床意义,并分析二者的相关性。方法选取2012年1月—2014年6月于我院口腔颌面外科诊治的69例OSCC患者作为OSCC组,同时选取43例口腔正常新鲜组织标本作为对照组。采用逆转录-聚合酶链反应技术检测组织中的MMP-14及EMMPRIN m RNA的表达含量。结果 MMP-14 m RNA、EMMPRIN m RNA在OSCC组中的相对表达量明显高于对照组,差异具有统计学意义(t=8.198、9.624,P0.01);OSCC组患者在年龄、性别因素中的MMP-14、EMMPRIN m RNA的表达差异不明显(P0.05),在伴有淋巴结转移的患者中均明显升高(t=2.909、2.156,P0.05);且MMP-14、EMMPRIN m RNA在Ⅲ~Ⅳ期、中低分化的OSCC中表达均明显升高,差异具有统计学意义(t=3.376、2.667、3.027、2.399,P0.05);MMP-14与EMMPRIN m RNA表达含量间相关系数为r=0.821,二者呈正相关性(P0.01)。结论 OSCC组织中MMP-14和EMMPRIN m RNA的高表达状态均与肿瘤的病理分期、分化程度及淋巴结转移因素关系密切,二者的表达具有正相关性,提示MMP-14和EMMPRIN均参与了OSCC的浸润及转移过程,通过检测EMMPRIN及MMP-14 m RNA表达含量可能有助于OSCC的病变程度及预后转归判断。
[Abstract]:Objective to investigate the clinical significance of matrix metalloproteinase-14 matrix metalloproteinase 14 (MMP-14) and extracellular matrix metalloproteinase inducer (EMMPRIN) in oral squamous cell carcinoma of oral squamous cell carcinoma (OSCC). Methods from January 2012 to June 2014, 69 patients with OSCC treated in oral and maxillofacial surgery in our hospital were selected as OSCC group. The expression of MMP-14 and EMMPRIN m RNA were detected by reverse transcription-polymerase chain reaction (RT-PCR). Results the relative expression of MMP-14 m RNAEMMPRIN m RNA in OSCC group was detected by reverse transcription-polymerase chain reaction (RT-PCR). The quantity was significantly higher than that in control group. There was no significant difference in the expression of MMP-14 EMMPRIN m RNA in age and sex factors in patients with OSCC. The expression of MMP-14 EMMPRIN m RNA in patients with lymph node metastasis was significantly higher than that in patients with lymph node metastasis, and the expression of MMP-14 EMMPRIN m RNA in patients with lymph node metastasis was significantly higher than that in patients with lymph node metastasis, and the expression of MMP-14 EMMPRIN m RNA in patients with lymph node metastasis was significantly higher than that in patients with lymph node metastasis, and the expression of MMP-14 EMMPRIN m in stage 鈪，

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