环二腺嘌呤核苷酸信号系统及其在口腔细菌致病机制中的研究展望

发布时间：2018-03-18 17:08

本文选题：环二腺嘌呤核苷酸　切入点：口腔细菌　出处：《国际口腔医学杂志》2017年06期 　论文类型：期刊论文

【摘要】：环二腺嘌呤核苷酸(c-di-AMP)是在继环腺嘌呤核苷酸(cAMP)、四(五)磷酸鸟嘌呤核苷((p)ppGpp)、环二鸟嘌呤核苷酸(c-di-GMP)后新发现的一种第二信使分子,在细菌和支原体中广泛存在。c-di-AMP调控细菌多项生理活动,如细胞周期、细胞壁稳定性、细胞形态、刺激宿主免疫反应以及应对外界环境胁迫等。本文总结了信使分子c-di-AMP自发现以来的研究进展,这些信息可丰富对c-di-AMP调控作用的全面理解。同时,生物信息学分析发现在口腔常见细菌(如变异链球菌和牙龈卟啉单胞菌等)基因组中均存在编码c-diAMP合成酶的基因,对于这一类基因的功能研究将为深入认识c-di-AMP信号系统在口腔细菌致病过程中的潜在作用提供重要线索,并为研究其在口腔细菌致病性中的调控机制开辟新天地。
[Abstract]:Two adenine nucleotides (c-di-AMP) ring is the ring of adenine nucleotide (cAMP), four (five) guanosine phosphate ((P) ppGpp), ring two guanine nucleotide (c-di-GMP) a second messenger molecule after new discovery,.C-di-AMP regulates multiple physiological activities of bacteria widely exists in bacteria and mycoplasma, such as cell cycle, cell wall stability, cell morphology, stimulation of the host immune response and response to environmental stress. This paper summarizes the research progress since the discovery of the messenger c-di-AMP, this information can enrich the comprehensive understanding of c-di-AMP regulation. At the same time, bioinformatics analysis found in oral bacteria (such as Streptococcus mutans and Porphyromonas gingivalis gingivalis etc.) are encoding c-diAMP synthase genes in the genome, the function of this kind of genes will be in-depth understanding of c-di-AMP signaling system in the process of oral pathogenic bacteria The potential role in the study provides important clues and opens up a new field for the study of its regulatory mechanism in oral bacterial pathogenicity.

【作者单位】：口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院;
【基金】：国家自然科学基金(31200985,81430011)~~
【分类号】：R780.2

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