腮腺良性肿瘤手术保留耳大神经临床价值Meta分析

发布时间：2018-03-27 07:10

本文选题：腮腺肿瘤　切入点：腮腺切除术　出处：《中华肿瘤防治杂志》2014年13期

【摘要】：目的:通过Meta分析评价腮腺良性肿瘤切除术中保留耳大神经(great auricular nerve,GAN)对术后各并发症发生率影响,探讨其临床价值。方法:以腮腺、耳大神经、并发症等为关键词对1997-04-2013-04期间PubMed、万方数据库等进行中英文文献检索,根据纳入及排除标准对纳入研究采用RevMan 5.0软件包进行荟萃分析。结果:12项涉及术后耳廓区暂时性感觉异常的研究中,共有366例出现症状,总发生率为50.76%,实验组(保留耳大神经)113例占27.56%,对照组(切除耳大神经)253例占81.35%,实验组较对照组的发生率降低53.79%,比值比(OR)及其95%置信区间(95%CI)为0.09(0.06~0.13),z=11.99,P0.01;6项关于术后味觉出汗综合征发生率的研究中,共74例出现症状,占总例数18.73%,实验组15例占7.50%,对照组59例占30.26%,前者较后者低22.76%,OR及其95%CI为0.18(0.10~0.35),z=5.18,P0.01;13项涉及影响生活质量并发症的研究中,243例出现不同症状,占总例数的31.93%,实验组62例占14.22%,对照组181例占55.69%,前者显著降低了41.47%,OR值及其95%CI为0.12(0.08~0.18),z=10.77,P0.01。结论:腮腺良性肿瘤手术能够对GAN进行功能保全,其不仅能够降低术后耳廓区暂时性感觉异常和味觉出汗综合征发生率,还能对其他影响生活质量的并发症加以控制,改善患者术后生活质量。
[Abstract]:Objective: to evaluate the influence of preserving great auricular nerve during parotid benign tumor resection on the incidence of postoperative complications by Meta analysis. Complications were analyzed by Chinese and English literature retrieval of PubMedand, Wanfang database between 1997-04 and 2013-04. According to the inclusion and exclusion criteria, RevMan 5.0 software package was used for meta-analysis of the inclusion study. Results in 12 studies involving temporary sensory abnormalities in the auricular area after operation, 366 cases developed symptoms. The total incidence rate was 50.76.The rates of the experimental group (113 cases of great auricular nerve preservation accounted for 27.56, the control group (253 cases of resection of the great auricular nerve and 81.35% of the control group) and the 95% confidence interval of 95% confidence interval (95% CI) of the experimental group decreased 53.79% and the 95% confidence interval (95% CI) respectively) were 0.09% 0.060.13z11.99% (P0.01). In the study of the incidence of sweating syndrome, A total of 74 cases (18.73%) developed symptoms, 15 cases in the experimental group (7.50%) and 59 cases in the control group (30.26%). The former was 22.76g / r lower than the latter and its 95%CI was 0.180.100.35 / 0.350.35 / 0 / 0 / 13. In the study of complications affecting the quality of life, 243 cases had different symptoms. There were 62 cases in the experimental group (14.22%) and 181 cases in the control group (55.69%). The former significantly decreased the OR value and its 95%CI value of 0.12 ~ 0.08 ~ 0.18 ~ 0.18 ~ (7) ~ (7) ~ (th) ~ P0.01.Conclusion: the parotid benign tumor operation can preserve the function of GAN. It can not only reduce the incidence of temporary sensory abnormality and taste sweating syndrome, but also control other complications that affect the quality of life, and improve the postoperative quality of life.
【作者单位】：泸州医学院附属医院肿瘤科;四川省肿瘤医院头颈肿瘤外科;
【基金】：2012年四川省科技厅应用基础项目(2012JY0125) 2011年四川省卫生厅科学研究项目(110259)
【分类号】：R739.8

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