细胞间黏附分子-1与牙周炎的关系

发布时间：2018-04-01 17:09

本文选题：ICAM-　切入点：牙周炎　出处：《牙体牙髓牙周病学杂志》2014年08期

【摘要】：细胞间黏附分子(Intercellular adhesion molecule,ICAM)是一类具有介导细胞与细胞、细胞与细胞外基质间黏附作用的生物大分子,多分布于细胞表面或细胞外基质。其在胚胎的发育分化、正常组织结构的维持、炎症与免疫应答、以及肿瘤的进展和转移等多种生理病理过程中均具有重要作用。近年来,ICAM-1(Intercellular adhesion molecule-1)作为免疫球蛋白超家族中的一员在牙周炎中的作用逐渐得到关注。在牙周致病菌的刺激下,ICAM-1可表达于牙周上皮细胞、成纤维细胞以及内皮细胞,并参与白细胞的趋化、黏附、迁移及增殖,从而使白细胞聚集于炎症部位,释放出大量炎性介质,最终导致对牙周组织的破坏。本文从ICAM-1在牙周组织中的表达分布、表达途径及其调节等方面对ICAM-1与牙周炎的关系作一综述。
[Abstract]:Intercellular adhesion molecule (ICAM) is a kind of biological macromolecules which can mediate the adhesion between cells and cells and between cells and extracellular matrix. The maintenance of normal tissue structure, inflammation and immune response, In recent years, ICAM-1 intercellular adhesion molecule-1, as a member of the immunoglobulin superfamily, has been paid more and more attention to in periodontitis. ICAM-1 was expressed in periodontal epithelial cells after stimulation. Fibroblasts and endothelial cells are involved in the chemotaxis, adhesion, migration and proliferation of white blood cells, resulting in the aggregation of leukocytes in the inflammatory site and the release of a large number of inflammatory mediators. This article reviews the relationship between ICAM-1 and periodontitis from the aspects of expression distribution, expression pathway and regulation of ICAM-1 in periodontitis.
【作者单位】：山东大学口腔医学院特诊科山东省口腔生物医学重点实验室;
【基金】：山东省自然科学基金(Y2008C99) 山东省科技攻关计划(2010GSF10270)
【分类号】：R781.42

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