新疆不同民族舌体鳞癌复发相关因素分析

发布时间：2018-04-04 05:57

本文选题：舌癌　切入点：鳞癌　出处：《中华肿瘤防治杂志》2014年17期

【摘要】：目的:探讨影响舌体鳞状细胞癌患者复发的临床病理因素。方法:选择2003-01-01-2011-12-31在新疆医科大学第一附属医院首治的经病理确诊,且随访资料完整的舌体鳞癌患者共136例。Kaplan-Meier计算累积生存率,组间差异采用Log-rank检验。Cox回归模型行多因素分析,确立影响复发的独立因素。结果:136例患者总复发率为52.94%(72/136),平均复发时间为34.05个月,中位复发时间为65个月。单因素分析结果显示,影响复发的因素为民族、病理分级、T分期、N分期、TNM分期、侵犯中线、侵犯口底、原发灶手术和是否行颈淋巴结清除术。多因素分析结果显示,影响复发的独立因素为T分期、N分期和是否行颈淋巴结清除术。隐匿性淋巴结转移率为14.89%(14/94),其中T1和T2发生隐匿性淋巴结转移率为15.19%(12/79),T3和T4发生隐匿性淋巴结转移率为13.33%(2/15),转移区域分布于Ⅰ~Ⅳ区,未见Ⅴ区转移。舌体鳞癌患者选择以手术为主的综合治疗可以降低复发率。结论:影响复发的独立危险因素为T分期、N分期和是否行淋巴结清除术。
[Abstract]:Objective: to investigate the clinicopathological factors influencing the recurrence of squamous cell carcinoma of tongue body.Methods: 136 cases of tongue squamous cell carcinoma with complete follow-up data were selected from the first affiliated Hospital of Xinjiang Medical University from January to January 2011-12-31, 2003. The cumulative survival rate was calculated by Kaplan-Meier. The difference between the two groups was analyzed by Log-rank test and Cox regression model.Establish independent factors affecting recurrence.Results the total recurrence rate of the 136 cases was 52.94%, the average recurrence time was 34.05 months and the median recurrence time was 65 months.Univariate analysis showed that the factors affecting recurrence were nationality, TNM staging, invasion of the median line, invasion of the floor of the mouth, primary tumor operation and neck lymph node dissection.Multivariate analysis showed that the independent factors affecting recurrence were T staging and cervical lymph node dissection.The occult lymph node metastasis rate was 14.89%. The occult lymph node metastasis rate of T 1 and T 2 was 15.19%. The occult lymph node metastasis rate of T 3 and T 4 was 13.3333 / 15%.The recurrent rate of tongue squamous cell carcinoma patients can be reduced by surgical treatment.Conclusion: the independent risk factors for recurrence are T stage N stage and lymph node dissection.
【作者单位】：新疆医科大学第一附属医院肿瘤中心;
【基金】：乌鲁木齐市科学技术项目(H111313001)
【分类号】：R739.86

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