牙周基础治疗对牙周炎伴冠状动脉性心脏病患者血清及龈沟液中单核细胞趋化蛋白1含量的影响

发布时间：2018-04-05 12:19

本文选题：牙周基础治疗　切入点：牙周炎　出处：《中华高血压杂志》2017年08期

【摘要】：目的研究牙周基础治疗对牙周炎伴冠状动脉性心脏病(冠心病)患者血清、龈沟液中单核细胞趋化蛋白1(MCP-1)含量的影响。方法根据冠心病和牙周炎的诊断标准及纳入标准,采用随机平行分组的方法入选福建医科大学附属第一医院口腔科的牙周炎伴冠心病患者46例,其中治疗组23例,进行牙周基础治疗,包括口腔卫生宣教、全口龈上洁治、龈下刮治、根面平整术、调牙合、拔除无法保留的牙;对照组23例,仅进行口腔卫生宣教,而不进行系统牙周基础治疗。于治疗前、治疗后3、6个月,检测血清和龈沟液中MCP-1含量,并记录出血指数、牙周袋探诊深度(PD)、附着丧失等指标。结果对照组治疗3、6个月后血清和龈沟液MCP-1水平与治疗前比较,差异无统计学意义(P0.05)。治疗组中,与治疗前比较,治疗3、6个月的血清MCP-1水平差异无统计学意义(P0.05),而龈沟液MCP-1水平明显减低[(15.80±3.27)、(17.10±8.08)比(28.62±18.65)μg/L,均P0.05]。与对照组比较,治疗组治疗3、6个月时的出血指数、PD和附着丧失明显降低(均P0.05)。结论牙周基础治疗可以降低牙周炎伴冠心病患者龈沟液内的MCP-1水平,对血清MCP-1水平影响较小。
[Abstract]:Objective to study the effect of periodontal basic therapy on monocyte chemoattractant protein 1 (MCP-1) in serum and gingival crevicular fluid (GCF) of patients with periodontitis and coronary heart disease (CHD).Methods according to the diagnostic criteria and inclusion criteria of coronary heart disease and periodontitis, 46 patients with periodontitis associated with coronary heart disease in the Department of Stomatology of the first affiliated Hospital of Fujian Medical University were randomly divided into treatment group (23 cases) and treatment group (23 cases).Basic periodontal treatment, including oral hygiene education, whole oral upper gingival scaling, subgingival curettage, root surface leveling, adjustment of occlusion, extraction of teeth that could not be retained, and control group (23 cases) were treated with oral hygiene education only.No systematic periodontal treatment was performed.The levels of MCP-1 in serum and gingival crevicular fluid were measured before treatment, 3 months and 6 months after treatment, and the indexes of bleeding index, depth of periodontal bag probing and attachment loss were recorded.Results the levels of MCP-1 in serum and gingival crevicular fluid in the control group were not significantly different from those before treatment 3 and 6 months after treatment (P 0.05).In the treatment group, there was no significant difference in serum MCP-1 level between 3 and 6 months after treatment, but the MCP-1 level in gingival crevicular fluid was significantly decreased [15.80 卤3.27, 17.10 卤8.08] compared with 28.62 卤18.65 渭 g / L, P0.05].Compared with the control group, the bleeding index (PD) and attachment loss in the treatment group were significantly lower than those in the control group at 3 and 6 months (all P 0.05).Conclusion periodontal basic therapy can reduce the level of MCP-1 in gingival crevicular fluid of patients with periodontitis and coronary heart disease, and has little effect on serum MCP-1 level.
【作者单位】：福建医科大学附属第一医院口腔科;
【基金】：中华口腔医学会口腔疾病与全身疾病关系研究项目(CSAY2015-09) 福建省自然科学基金资助项目(2017J05124)
【分类号】：R541.4;R781.42

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