表观遗传学及其调控与牙周病

发布时间：2018-04-06 22:21

本文选题：表观遗传学　切入点：牙周病　出处：《国际口腔医学杂志》2017年05期

【摘要】：表观遗传学是指不涉及DNA序列改变,而是通过有丝分裂和减数分裂进行遗传的基因表达变化的遗传学分支学科,其调控机制主要包括DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA调控等。牙周炎病因复杂,且被吸收、破坏的牙槽骨很难实现功能性再生。表观遗传学在导致炎症的发生及促进骨再生的过程中扮演着重要角色,从表观遗传学及其调控的角度来预防牙周病的发生,促进牙槽骨的功能性再生,将是未来重要的研究内容,具有重要的临床意义。
[Abstract]:Epigenetics is a branch of genetics that does not involve changes in DNA sequences but changes in genetic expression through mitosis and meiosis. Its regulatory mechanisms include DNA methylation and histone modification.Chromatin remodeling and non-coding RNA regulation.The etiology of periodontitis is complex and absorbed, and the damaged alveolar bone is difficult to achieve functional regeneration.Epigenetics plays an important role in the process of inflammation and bone regeneration. Epigenetics and its regulation are used to prevent periodontal disease and promote functional regeneration of alveolar bone.Will be the future important research content, has the important clinical significance.
【作者单位】：山东大学口腔医院牙周科山东省口腔组织再生重点实验室;
【分类号】：R781.4

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