填料协同增强增韧光固化树脂基口腔材料的制备、性能及生物力学评价

发布时间：2018-04-10 02:25

本文选题：生物相容性材料　切入点：口腔　出处：《中国组织工程研究》2017年10期

【摘要】：背景:光固化复合树脂由于色泽美观、优良的物理、化学性能及操作简单等在牙科缺损修复中得到应用。但是,复合树脂由于力学性能不足容易引起复合体折断,导致临床使用难以达到预期治疗效果。目的:探讨填料协同增强增韧光固化树脂基口腔材料的制备方法、性能及生物力学特征。方法:以原子转移自由基聚合方法对纳米二氧化硅进行表面接枝聚甲基丙烯酸甲酯(SiO_2-PMMA)改性,获得接枝SiO_2-PMMA,利用同轴静电纺丝方法制备聚丙烯腈/聚甲基丙烯酸甲酯核-壳纳米纤维,以铜网作为接收装置获得具备网格结构的二维乳酸-羟基乙酸共聚物纳米纤维膜。以硅烷偶联剂为原乙酯前驱体溶胶-沉淀法制备多尺度、多维度填料,采用硅烷偶联剂进行改性。将接枝SiO_2-PMMA核-壳纳米纤维、梯形聚硅氧烷材料与光固化树脂基体进行复合,比较两种复合树脂材料的力学性能、体积收缩率、毒性、降解性能等。结果与结论:(1)复合树脂断裂形貌的电镜表征:填料接枝SiO_2-PMMA核-壳纳米纤维在光固化树脂基体中能较好的分散,团聚现象相对较少,存在单分散现象;而梯形聚硅氧烷材料在光固化树脂基体中分散不均匀,且在复合树脂中甚至出现团聚现象;(2)弯曲强度、弯曲模量及断裂功:填料接枝SiO_2-PMMA核-壳纳米纤维光固化树脂基口腔材料的弯曲强度、弯曲模量及断裂功显著高于梯形聚硅氧烷材料光固化树脂基口腔材料(P0.05);(3)体积收缩率:填料接枝Si O2-PMMA核-壳纳米纤维光固化树脂基口腔材料的体积收缩率低于梯形聚硅氧烷材料光固化树脂基口腔材料(P0.05);(4)性能测定:填料接枝Si O2-PMMA核-壳纳米纤维光固化树脂基口腔材料吸水性及细胞毒性A值高于梯形聚硅氧烷材料光固化树脂基口腔材料(P0.05),而溶解值低于梯形聚硅氧烷材料光固化树脂基口腔材料(P0.05);(5)提示制备的填料协同增强增韧光固化树脂基口腔材料具备优良的性能和生物力学特征。
[Abstract]:Background: light-cured composite resin has been applied in dental defect repair because of its beautiful color, excellent physical and chemical properties and simple operation.However, due to the lack of mechanical properties of composite resin, it is easy to cause the complex to break, which makes it difficult to achieve the expected therapeutic effect in clinical use.Objective: to study the preparation, properties and biomechanical characteristics of the stuffing synergistic reinforcing light curing resin based oral materials.Methods: surface grafted poly (methyl methacrylate) sio _ 2-PMMA was modified by atom transfer radical polymerization.SiO2-PMMA was grafted onto SiO2-PMMA.The coaxial electrospinning method was used to prepare polyacrylonitrile / poly (methyl methacrylate) core-shell nanofibers. A two-dimensional lactic acid-glycolic acid copolymer nanofiber film with grid structure was obtained by using copper mesh as the receiving device.Using silane coupling agent as precursor of ethyl ester sol-precipitation method, multi-dimensional and multi-dimensional fillers were prepared and modified by silane coupling agent.The grafted SiO_2-PMMA core-shell nanofibers, trapezoidal polysiloxane materials and light-cured resin matrix were combined to compare the mechanical properties, volume shrinkage, toxicity and degradation properties of the two composite resins.Results and conclusion the fracture morphology of the composite resin was characterized by electron microscope: the filler grafted SiO_2-PMMA core-shell nanofibers could be dispersed in the resin matrix, and the agglomeration phenomenon was relatively small, and the phenomenon of monodispersity existed.However, the trapezoidal polysiloxane material was dispersed inhomogeneously in the light curing resin matrix, and even agglomerated in the composite resin.Flexural modulus and fracture work: flexural strength of SiO_2-PMMA core shell nano-fiber photocurable resin based oral materials grafted with filler,The flexural modulus and fracture work were significantly higher than those of trapezoidal polysiloxane photocurable resin based oral materials (P 0.05 / 3). The volume shrinkage rate of filler grafted Si O2-PMMA core shell nano-fiber photocurable resin based oral materials was lower than that of trapezoidal polysiloxane materials.Determination of the Properties of Polysiloxane Resin based Stomaterials (P0.05): the absorbency and Cytotoxicity A value of packed Si O2-PMMA Nano-fiber Photocurable Resin-based Oral Materials is higher than that of trapezoid Polysiloxane Photocurable ResinsThe results showed that the fillers had excellent properties and biomechanical properties, while the dissolution value was lower than that of trapezoid polysiloxane materials.
【作者单位】：宜宾市第一人民医院口腔科;西南医科大学;
【基金】：四川省卫生科技创新项目(2014K0122)~~
【分类号】：R783.1

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