锶纳米羟基磷灰石原花青素复合涂膜对牙本质小管的封闭作用

发布时间：2018-04-23 09:59

本文选题：原花青素 + 渗透型丙烯酸树脂　；参考：《第三军医大学学报》2017年07期

【摘要】：目的检测自主合成的锶纳米羟基磷灰石原花青素(strontium-substituted-hydroxyapatite varnish,SrHAP-PA)复合涂膜对牙本质小管的封闭作用。方法首先构建牙本质敏感体外研究模型,并在模拟人口腔环境的条件下检测SrHAP-PA复合涂膜对牙本质小管的封闭作用,用扫描电镜观察循环结束后各组牙本质小管的封闭情况,X线能谱分析牙本质表面元素变化,记录各组傅里叶红外光谱,并用激光共聚焦扫描显微镜观察药品进入牙本质小管情况。结果成功构建了体外牙本质敏感的模型,并且在扫描电子显微镜下观察到SrHAP-PA复合涂膜能有效地封闭牙本质小管,X线能谱分析检测发现SrHAP-PA复合涂膜促进矿化物的形成,激光共聚焦扫描显微镜观察到该涂膜能快速进入到牙本质小管中,且能保存较长时间。结论以SrHAP-PA复合物为有效成分的涂膜材料能有效封闭牙本质小管。
[Abstract]:Methods the model of dentin sensitivity in vitro was established, and the sealing effect of SrHAP-PA composite coating on dentine tubules was detected under simulated human oral environment. The closure of dentine tubules in each group was observed by scanning electron microscope (SEM). The changes of elements on dentin surface were analyzed by X-ray energy dispersive spectroscopy, and Fourier infrared spectroscopy was recorded in each group. Laser confocal scanning microscope was used to observe the entry of drugs into dentin tubules. Results the model of dentin sensitivity in vitro was successfully constructed, and it was observed under scanning electron microscope that the SrHAP-PA composite film could effectively seal the dentine tubule X ray energy spectrum analysis. It was found that the SrHAP-PA composite film promoted the formation of mineralized material. Laser confocal scanning microscopy showed that the coating could enter the dentine tubules quickly and keep for a long time. Conclusion the coating material with SrHAP-PA complex as effective component can effectively seal dentin tubules.
【作者单位】：重庆医科大学附属口腔医院预防口腔科;重庆医科大学附属口腔医院口腔疾病与生物医学重庆市重点实验室重庆市高校市级口腔生物医学工程重点实验室;
【基金】：重庆市卫生局医学科研计划重点项目(2013-1-032) 重庆市中医药管理局项目(ZY20132111) 重庆市渝北区科技项目[2014(社)-13号] 重庆市卫生计生委医学科研项目(2015MSXM049) 2016年重庆高校创新团队建设计划资助项目(CXTDG201602006)~~
【分类号】：R781.2

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