西帕依固龈液治疗单纯性牙龈炎随机对照试验的Meta分析

发布时间：2018-04-27 02:09

本文选题：西帕依固龈液 + 单纯性牙龈炎　；参考：《中国实验方剂学杂志》2014年19期

【摘要】：目的:系统评价西帕依固龈液治疗单纯性牙龈炎的临床疗效。方法:计算机检索CNKI中国知网(总库)(1979—2012)、维普期刊资源整合服务平台(1989—2013)、美国图书馆PubMed/MEDLINE相关文献。根据Jadad量表对纳入文献进行质量评价。采用Cochrane协作网提供的RevMan 5.2.0分析软件进行Meta分析。结果:共纳入6项临床随机对照研究,共490例单纯性牙龈炎患者。Meta分析结果显示,西帕依固龈液与安慰剂比较治疗单纯性牙龈炎龈沟出血指数(sulcus bleeding index,SBI)[WMD=-0.59,95%CI(-0.76,-0.42)]、菌斑指数(plaque index,PLI)[MD=-0.67,95%CI(-1.03,-0.30)];西帕依固龈液与西药比较治疗单纯性牙龈炎SBI[MD=-0.02,95%CI(-0.14,0.10)],PLI[MD=0.03,95%CI(-0.24,0.30)]。结论:西帕依固龈液治疗单纯性牙龈炎疗效优于安慰剂,与西药作用相似,可降低龈沟出血指数及菌斑指数,且无明显副作用,服用方便。由于纳入研究样本量小且质量较低,尚需开展高质量、多中心、大样本的临床随机双盲对照试验加以证实。
[Abstract]:Objective: to evaluate the clinical effect of cipail gingival fluid in the treatment of simple gingivitis. Methods: CNKI China Information Network (CNKI) was searched by computer (General Library: 1979-2012, WIP periodical Resources Integration Service platform, 1989-2013), PubMed/MEDLINE related documents of American Library. The quality of the literature was evaluated according to the Jadad scale. RevMan 5.2.0 analysis software provided by Cochrane cooperation network is used for Meta analysis. Results: a total of 490 patients with simple gingivitis were included in 6 randomized controlled trials. Compared with placebo, sipanil compared with placebo for the treatment of simple gingivitis with sulcus bleeding indexSBI [WMD-0.59 ~ 9595 CI-0.76 + -0.42], plaque index (PLI) [MD-0.6795CI-1.03- 0.30]; sipanil compared gingival fluid with western medicine in the treatment of simple gingivitis SBI [MD-0.0295CI-0.140.10] [MD-0.0395CI-0.240.30]. Conclusion: the treatment of simple gingivitis with Cipayl gingival fluid is superior to placebo, similar to western medicine, it can reduce the bleeding index of gingival sulcus and plaque index, and has no obvious side effect and is convenient to take. Because the sample size is small and the quality is low, high quality, multi-center, large sample clinical double-blind controlled trial should be carried out.
【作者单位】：新疆医科大学;新疆医科大学附属中医医院;
【基金】：国家自然科学基金项目(81360167)
【分类号】：R781.4

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