右美托咪啶对口腔颌面肿瘤根治术患者经鼻清醒插管应激反应的影响

发布时间：2018-04-30 03:38

本文选题：右美托咪啶 + 清醒镇静　；参考：《实用医学杂志》2017年17期

【摘要】：目的评价右美托咪啶对口腔颌面肿瘤根治术患者经鼻清醒插管应激反应的影响。方法选取择期行口腔颌面肿瘤根治术患者40例,ASAⅠ或Ⅱ级,年龄20~62岁,性别不限,体质指数25。按随机数字表法分为两组(n=20):右美托咪啶组(D组)和咪达唑仑组(M组)。记录平均动脉压(MAP)、心率(HR)、血氧饱和度(Sp O2)变化,记录呼吸抑制发生率、患者对插管过程的耐受程度、患者的配合程度和术后对插管过程的不良记忆情况。结果两组T1的HR比T0时较均升高,差异具有统计学意义(P0.05)。M组T1-2时的MAP和HR及T3时HR比T0时升高,差异具有统计学意义(P0.05)。与M组比较,D组T1-2时的MAP和HR,T3时HR降低,差异具有统计学意义(P0.05)。D组呼吸抑制发生率较M组降低,气管插管舒适度和配合程度评分较M组降低(P0.05)。结论右美托咪啶可以减轻口腔颌面肿瘤根治术患者经鼻清醒气管插管的应激反应,提高患者舒适度,减少呼吸抑制发生率,维持血流动力学稳定,保证了插管的安全性。
[Abstract]:Objective to evaluate the effect of dexmetidine on stress response in patients undergoing radical resection of oral and maxillofacial tumors. Methods A total of 40 patients with oral and maxillofacial neoplasms underwent radical resection of oral and maxillofacial tumors, aged 20 to 62 years, aged 20 to 62 years, with body mass index (BMI) of 25. According to the method of random number table, they were divided into two groups: dexmetomidine group (group D) and midazolam group (group M). The changes of mean arterial pressure (map), heart rate (HRN) and oxygen saturation (Sp / O _ 2) were recorded. The incidence of respiratory inhibition, the tolerance of patients to intubation, the degree of cooperation of patients and the bad memory during intubation were recorded. Results the HR of T1 was higher than that of T0, the difference was statistically significant (P 0.05). The MAP and HR of group M at T1-2 and HR at T3 were higher than those of T0. The difference was statistically significant (P 0.05). Compared with group M, the MAP and HR at T1-2 and HRT 3 in group D were significantly lower than those in group M, and the incidence of respiratory inhibition in group D was lower than that in group M, and the score of tracheal intubation comfort and cooperation degree was lower than that in group M (P 0.05). Conclusion dexmetidine can reduce the stress response of tracheal intubation in patients with oral and maxillofacial neoplasms, increase the comfort of patients, reduce the incidence of respiratory inhibition, maintain hemodynamic stability, and ensure the safety of intubation.
【作者单位】：河北省眼科医院麻醉科;河北医科大学第一医院麻醉科;
【分类号】：R614;R739.8

【相似文献】