腮腺癌组织PAX2和PAX8表达联合预测其根治术后复发、转移的价值

发布时间：2018-05-01 12:28

本文选题：腮腺肿瘤 + 成对盒基因　；参考：《重庆医学》2017年31期

【摘要】：目的探讨腮腺癌组织成对盒基因2(PAX2)和成对盒基因8(PAX8)表达联合预测其根治术后复发、转移的价值。方法以行腮腺颈联合根治术治疗的腮腺癌患者46例为研究对象。采用免疫组织化学法检测其手术切除腮腺癌组织及癌旁组织中PAX2和PAX8蛋白表达水平。结果腮腺癌组织PAX2和PAX8蛋白阳性表达率分别为76.09%和69.57%,均高于癌旁组织的26.09%和28.26%(P0.05)。腮腺癌根治术治疗患者随访3年的局部复发率为41.30%,淋巴结转移率为34.78%。且PAX2蛋白阳性表达患者的复发率和转移率均高于其阴性表达患者,PAX8蛋白阳性表达患者的复发率和转移率亦均高于其阴性表达患者(P0.05)。Logistic回归分析结果显示,腮腺癌组织PAX2和PAX8表达水平与其根治术后复发、转移均密切相关(P0.05)。腮腺癌组织PAX2和PAX8表达水平预测其术后复发、转移的价值良好,其中以PAX2阳性和PAX8阳性预测其术后复发、转移的价值最优。结论腮腺癌组织PAX2和PAX8表达水平与其根治术后复发、转移等预后情况的密切相关且联合预测其预后的价值良好,联合检测腮腺癌组织PAX2和PAX8蛋白表达可作为腮腺癌根治术预后评估的参考指标。
[Abstract]:Objective to investigate the value of the expression of pairwise box gene 2 (PAX2) and pairwise box gene 8 (PAX8) in predicting recurrence and metastasis after radical resection. Methods 46 cases of parotid carcinoma treated by combined operation of parotid neck and radical resection were studied. Immunohistochemical method was used to detect the expression of PAX2 and PAX8 protein in parotid carcinoma tissues and paracancerous tissues. Results the positive expression rates of PAX2 and PAX8 in parotid carcinoma were 76.09% and 69.57, respectively, which were higher than those in paracancerous tissues (26.09% and 28.26P 0.05). The local recurrence rate and lymph node metastasis rate were 41.30 and 34.78 respectively. The recurrence rate and metastasis rate of patients with positive expression of PAX2 protein were higher than those of patients with positive expression of PAX8 protein, and the recurrence rate and metastasis rate of patients with positive expression of PAX2 protein were higher than those of patients with negative expression of PAX8 protein. The expression of PAX2 and PAX8 in parotid carcinoma was closely related to the recurrence and metastasis of parotid carcinoma after radical operation (P 0.05). The expression level of PAX2 and PAX8 in parotid gland carcinoma can predict the recurrence and metastasis of parotid gland carcinoma after operation. Among them, the positive PAX2 and PAX8 are the best predictors of postoperative recurrence, and the value of metastasis is the best. Conclusion the expression of PAX2 and PAX8 in parotid carcinoma is closely related to the prognosis of recurrence and metastasis after radical mastectomy. Combined detection of PAX2 and PAX8 protein expression in parotid carcinoma can be used as a reference index for prognosis evaluation of parotid carcinoma after radical mastectomy.
【作者单位】：广东省汕头市中心医院口腔科;中山大学孙逸仙纪念医院口腔科;
【分类号】：R739.8

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