正畸牙移动对大鼠血清及局部牙周组织雌激素水平影响的研究

发布时间：2018-05-04 23:24

本文选题：雌激素 + 正畸牙移动　；参考：《口腔医学研究》2017年03期

【摘要】：目的:研究正畸牙移动对大鼠血清及局部牙周组织雌激素水平的影响。方法:选取105只wistar雌性大鼠,建立正畸牙移动实验模型,按照处理方式的不同,随机分为A(假处理组)、B(加力实验组)、C(空白对照组)3组,每组各35只,各组同时分为动情前期、动情期、动情后期、动情间期4个亚组,采用放射免疫法对大鼠血清雌激素水平进行测定,采用免疫组织化学法对大鼠局部牙周组织雌激素水平进行测定。结果:大鼠动情前期及动情期血清及局部牙周组织雌激素水平与动情后期及动情间期相比,均具有统计学差异(P0.05);正畸牙移动可促使动情前期、动情期、动情后期、动情间期4个阶段中大鼠的血清及局部牙周组织雌激素水平显著增加(P0.05)。结论:正畸牙移动促使血清雌激素水平增加,与全身应激反应有关;促使局部牙周组织雌激素水平增加,与局部应力作用下的牙周改建有关。
[Abstract]:Objective: To study the effect of orthodontic tooth movement on the estrogen level in the serum and local periodontium of rats. Methods: 105 Wistar female rats were selected and the orthodontic tooth movement model was established. According to the different treatment methods, they were randomly divided into A (false treatment group), B (experiment group) and C (blank control group), 35 rats in each group. Each group was divided into estrus at the same time. The 4 subgroups of prophase, estrus, anaphase, and estrus were measured by radioimmunoassay. The estrogen levels in the local periodontium of rats were measured by immunohistochemical method. Results: the estrogen levels in the serum and the local periodontium and the anaphase and movement of the estrus and the local periodontium in the preoestrus and estrus stage of the rats. There were statistical differences (P0.05). Orthodontic tooth movement could increase the level of estrogen in the serum and local periodontium of rats during the 4 stages of estrus, oestrus, anaphase and estrus (P0.05). Conclusion: orthodontic tooth movement increases the level of serum estrogen and is related to the systemic stress response; The increased level of estrogen in periodontal tissues is related to periodontal remodeling under local stress.

【作者单位】：黑龙江省医院南岗院区口腔科;
【基金】：黑龙江省自然基金面上项目(编号:H2016044)
【分类号】：R783.5

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