不同剂型曲安奈德治疗糜烂型口腔扁平苔藓的短期疗效评价

发布时间：2018-05-10 05:34

本文选题：曲安奈德(TA) + 糜烂　；参考：《实用口腔医学杂志》2016年06期

【摘要】：目的:观察不同剂型曲安奈德治疗双颊糜烂型口腔扁平苔藓(OLP)的疗效。方法:将120例符合纳入标准的OLP患者随机分为4组(n=30):分别采用局部涂布曲安奈德口腔软膏(A组)、曲安奈德注射液局部封闭(B组)、曲安奈德漱口液(C组)进行治疗,3个实验组及对照组患者均用康复新液含漱,比较4组的糜烂症状及疼痛改善情况(VAS评分)。结果:3个实验组治疗1、2、4周的VAS评分均明显低于对照组,总有效率明显均高于对照组(P0.05);A组及B组VAS评分和总有效率明显优于C组,差异有统计学意义(P0.05),但A组与B组间比较差异无统计学意义(P0.05);A组及B组治疗1、2、4周后病损糜烂面积均值明显均低于对照组(P0.05),C组治疗1、2周后与对照组无明显差异,治疗4周后明显低于对照组(P0.05)。结论:曲安奈德治疗OLP疗效较好,口腔软膏是治疗OLP安全有效并且方便的药物。
[Abstract]:Objective: to observe the therapeutic effect of triamcinolone acetonide (triamcinolone acetonide) on oral lichen planus (OLP). Methods: 120 patients with OLP were randomly divided into 4 groups: group A was treated with triamcinolone acetonide oral ointment, group A with triamcinolone acetonide injection, group B with triamcinolone acetonide injection and group C with triamcinolone acetonide gargle. , the three experimental groups and the control group were all gargled with Kangangxin solution. The symptoms of erosion and the improvement of pain were compared in 4 groups. Results: the VAS scores of the three experimental groups were significantly lower than those of the control group for 4 weeks, and the total effective rate was significantly higher than that in the control group (P 0.05) and group B (VAS score) and the total effective rate was significantly better than that in the C group. The difference was statistically significant (P 0.05), but there was no significant difference between group A and group B. The mean value of erosive area in group A and group B was significantly lower than that in group A and group B after treatment for 1 week and 2 weeks after treatment, and there was no significant difference between group A and group B after treatment for 1 week or 2 weeks. After 4 weeks of treatment, it was significantly lower than that of control group (P 0.05). Conclusion: triamcinolone acetonide is effective in the treatment of OLP. Oral ointment is a safe, effective and convenient drug for OLP.
【作者单位】：中国医科大学口腔医学院口腔急诊·黏膜病科;
【分类号】：R781.5

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