S100A7蛋白在口腔黏膜下纤维性变组织中的表达

发布时间：2018-05-13 14:40

本文选题：SA + 口腔黏膜下纤维性变　；参考：《中国现代医学杂志》2015年22期

【摘要】：目的检测口腔黏膜下纤维性变(OSF)患者颊黏膜和正常颊黏膜中S100A7的表达,探讨S100A7在OSF的发生、发展中的作用。方法收集10例正常颊黏膜组织、49例OSF患者颊黏膜组织(其中早期14例,中期19例,晚期16例),用免疫组化方法检测其S100A7的表达,比较并分析其表达差异。结果 1正常组和OSF早期组的S100A7阳性率(分别为0.0%和28.6%),差异无统计学意义(P0.05),OSF中期组和晚期组的阳性率(分别为78.9%和93.8%),差异也无统计学意义(P0.05),但OSF中期组和晚期组的阳性率皆高于正常组和OSF早期组,差异有统计学意义(P0.05);2S100A7的表达量依次为:正常组(0.60±0.52)OSF早期组(2.07±1.00)OSF中期组(3.95±1.18)OSF晚期组(5.25±1.24),各组两两之间差异具有统计学意义(P0.05)。结论 S100A7在OSF中表达升高,提示S100A7在OSF的发生、发展中可能起重要作用,有望作为评价OSF发生、发展的指标。
[Abstract]:Objective to detect the expression of S100A7 in buccal mucosa and normal buccal mucosa of patients with submucous fibrosis of oral cavity, and to investigate the role of S100A7 in the pathogenesis and development of OSF. Methods the expression of S100A7 in 10 cases of normal buccal mucosa and 49 cases of OSF (14 cases in early stage, 19 cases in middle stage and 16 cases in late stage) were detected by immunohistochemical method, and the difference of S100A7 expression was compared and analyzed. Results 1 the positive rate of S100A7 in normal group and early OSF group was 0.06% and 28.60.The difference was not statistically significant (78.9% and 93.8%, respectively), but there was no significant difference between middle OSF group and late stage group (P 0.05). The positive rates were higher in both normal group and early OSF group. There was a significant difference in the expression of P0.05T2S100A7 in the normal group (0.60 卤0.52)OSF), the middle group (2.07 卤1.00)OSF) and the late stage (3.95 卤1.18)OSF) (5.25 卤1.24). The difference between the two groups was statistically significant (P 0.05). Conclusion the increased expression of S100A7 in OSF suggests that S100A7 may play an important role in the occurrence and development of OSF, which may be used as an index to evaluate the occurrence and development of OSF.
【作者单位】：中南大学湘雅医院口腔医学中心;解放军163医院病理科;
【基金】：S100A7在口腔黏膜下纤维性变组织中的作用机制研究(No:2013SK3024)
【分类号】：R781.5

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