多联抗生素糊剂与Vitapex治疗乳牙牙髓病及根尖周病疗效的系统评价

发布时间：2018-05-14 00:21

本文选题：多联抗生素糊剂 + Vitapex　；参考：《口腔医学研究》2017年04期

【摘要】：目的:系统评价多联抗生素糊剂与Vitapex用于乳牙牙髓病及根尖周病的疗效。方法:计算机检索Cochrane Library、EMbase、PubMed、CBM、CNKI及VIP数据库,检索从建库到2016年6月30日国内外公开发表的关于比较多联抗生素糊剂与Vitapex治疗乳牙牙髓及根尖周病的随机对照试验,由2名研究者根据纳入及排除标准独立筛选文献、提取数据并对纳入文献进行方法学质量评价,最后采用RevMan 5.0软件进行Meta分析,Stata12.0进行发表偏倚的衡量。结果:最终纳入16个研究3852颗牙齿。Meta分析结果显示,整体成功率[RR=1.02,95%CI(1.00-1.04),Z=1.85,P=0.06]及12个月成功率[RR=1.01,95%CI(0.98-1.03),Z=0.60,P=0.55]比较差异无统计学意义,6个月成功率[RR=1.02,95%CI(1.00-1.04),Z=2.15,P=0.03]及24个月及以上成功率[RR=1.07,95%CI(1.01-1.12),Z=2.42,P=0.02]比较差异有统计学意义。结论:对于乳牙根管治疗,多联抗生素糊剂与Vitapex具有可比性,且随访2年及以上的长期效果较Vitapex更稳定。
[Abstract]:Objective: to evaluate the efficacy of multiplex antibiotic paste and Vitapex in the treatment of primary pulp disease and periapical disease. Methods: the Cochrane Library EMbase Cochrane and VIP databases were searched, and a randomized controlled trial was published from the establishment of the database to June 30, 2016, which was published at home and abroad, comparing the treatment of primary dental pulp and periapical disease with Vitapex, and compared with Vitapex in the treatment of primary dental pulp and periapical disease. According to the inclusion and exclusion criteria, two researchers independently sifted the literature, extracted the data and evaluated the methodological quality of the included literature. Finally, the publication bias was measured by Meta analysis with RevMan 5.0 software. Results: the results of Meta-analysis showed that there was no significant difference between the overall success rate [RRN 1.0295 CIQ 1.00-1.04J] and the 12-month success rate (RR1.01C95CII 0.98-1.03CII 0.60P0.55). The 6-month success rate was 1.00-1.0495 CI 1.00-1.04Z 2.15p 0.03, and the 24 months and above was 1.01-1.122P 0.02. There was significant difference in the total success rate of 6 months [RRH1.0295CIT 1.00-1.04Z] and the 24 months and more success rates (RR1.0795CI1.01-1.12C 1.42P0.02). Conclusion: for root canal therapy of deciduous teeth, multiplex antibiotic paste is comparable to Vitapex, and the long-term effect of 2 years and more follow-up is more stable than that of Vitapex.
【作者单位】：军事口腔医学国家重点实验室口疾病国家临床医学研究中心第四军医大学口腔医学院儿童口腔科;
【基金】：国家自然科学基金(编号:81170929)
【分类号】：R781.3

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