顺铂、5-氟尿嘧啶持续动脉灌注化疗对口腔癌的临床疗效及安全性评价

发布时间：2018-05-14 21:44

本文选题：动脉灌注化疗 + 口腔癌　；参考：《中国临床药理学杂志》2015年15期

【摘要】：目的评价顺铂、5-氟尿嘧啶区域性持续动脉灌注化疗对口腔癌的疗效及安全性。方法入选口腔癌患者82例,随机分为对照组40例和试验组42例。对照组用肌内注射平阳霉素8 mg,每日1次;试验组以微量注射泵持续动脉灌注顺铂100 mg·m-224 h,第1天+5-氟尿嘧啶1000 mg·m-2持续灌注72 h,21 d为一个化疗周期,2组患者均化疗3个周期。比较2组患者的客观反应率(ORR)及不良反应发生情况。结果对照组客观缓解率为57.5%,显著低于试验组的78.6%(P0.05)。试验组发生恶心呕吐8例(19.05%),骨髓抑制1例(2.38%);对照组分别为14例(35.00%),3例(7.50%),试验组总体不良反应发生率为42.50%,显著低于对照组21.43%(P0.05)。结论顺铂、5-氟尿嘧啶区域性持续动脉灌注化疗对口腔癌的疗效显著,不良反应发生率低。
[Abstract]:Objective to evaluate the efficacy and safety of cisplatin 5-fluorouracil continuous arterial infusion chemotherapy for oral cancer. Methods 82 patients with oral cancer were randomly divided into control group (n = 40) and trial group (n = 42). The control group received intramuscular injection of pingyangmycin 8 mg once a day, and the experimental group received continuous arterial infusion of cisplatin 100mg m-224 h with a microinjection pump, and 5-fluorouracil 1000 mg m-2 for 72 h 21 days on the first day as a chemotherapy cycle. Objective response rate (ORR) and adverse reaction (ADR) were compared between the two groups. Results the objective remission rate in the control group was 57.5%, which was significantly lower than that in the test group (78.6%). There were 8 cases of nausea and vomiting and 1 case of bone marrow suppression in the trial group, and 14 cases in the control group, 3 cases in the control group and 3 cases in the control group, respectively. The overall adverse reaction rate in the trial group was 42.50, which was significantly lower than that in the control group (21.43%, P 0.05). Conclusion Cisplatin 5-fluorouracil regional continuous arterial infusion chemotherapy is effective for oral cancer with low incidence of adverse reactions.
【作者单位】：温州医科大学附属第六人民医院口腔科;
【基金】：丽水市科技计划资金资助项目(2013ZC014)
【分类号】：R739.8

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