整合素连接激酶和基质金属蛋白酶-9在涎腺腺样囊性癌中的表达及意义

发布时间：2018-05-15 10:44

本文选题：涎腺腺样囊性癌 + 整合素连接激酶　；参考：《口腔医学研究》2016年07期

【摘要】：目的:探讨整合素连接激酶(ILK)和基质金属蛋白酶-9(MMP-9)在涎腺腺样囊性癌(SACC)中的表达及意义。方法:选取59例SACC患者和42例非肿瘤患者正常涎腺组织,利用qRT-PCR技术检测ILK和MMP-9在SACC组织中表达。结果:SACC组织中ILK mRNA和MMP-9mRNA相对表达量均高于对照组,差异均有统计学意义(P0.05);ILK和MMP-9在SACC组织中表达均与组织类型、淋巴结转移、TNM分期有关(P0.05),实体型和管状型SACC组织中ILK mRNA和MMP-9mRNA相对表达量均高于筛状型(P0.05);Pearson相关分析显示,SACC组织中ILK mRNA相对表达量与MMP-9mRNA相对表达量呈正相关(r=0.586,P=0.000)。结论:ILK和MMP-9在SACC组织中呈高表达,可能共同协同参与了肿瘤细胞侵袭、转移过程。
[Abstract]:Objective: to investigate the expression and significance of integrin linked kinase (ILK) and matrix metalloproteinase-9 (MMP-9) in salivary adenoid cystic carcinoma (SACC). Methods: 59 cases of SACC and 42 cases of normal salivary gland tissues were selected to detect the expression of ILK and MMP-9 in SACC tissue by qRT-PCR technique. Results the relative expression levels of ILK mRNA and MMP-9mRNA in the tissues of ILK mRNA and MMP-9mRNA were higher than those in the control group, and the difference was statistically significant (P 0.05). The expression of ilk and MMP-9 in the tissues of SACC was similar to the type of tissue. The relative expression of ILK mRNA and MMP-9mRNA in solid and tubular SACC tissues was higher than that in sieve type P0.05P Pearson correlation analysis showed that there was a positive correlation between the relative expression of ILK mRNA and the relative expression of MMP-9mRNA. Conclusion the expression of MMP-9 and wlk is high in SACC tissues, which may be involved in the invasion and metastasis of tumor cells.
【作者单位】：焦煤集团中央医院口腔科;
【分类号】：R739.87

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