乳牙根管充填用碘仿糊的处方优化研究

发布时间：2018-05-16 20:43

本文选题：碘仿糊剂 + 乳牙　；参考：《中国药学杂志》2017年02期

【摘要】：目的优化乳牙根管充填用碘仿糊的处方。方法以糊剂的细腻程度、润滑性、根管充填难易程度、去除难易程度等作为考察指标,采用多指标综合评分法对基质种类进行筛选,采用正交试验设计法对处方比例进行优化;并采用紫外分光光度法对优化处方中碘仿进行含量测定。结果多指标综合评分法选择二甲基硅油作为糊剂基质。正交试验结果显示,碘仿/氧化锌比例为影响糊剂的主要因素,确定优化处方为:碘仿/氧化锌比例为3∶7、丁香油比例为1.5%、粉/液比例为70∶30。优化处方中碘仿测定的线性方程为A=6.781 3C-0.051 6(r=0.999 7),表明碘仿浓度在48.75~146.26μg·m L~(-1)内与吸收度呈良好的线性关系,平均回收率为99.83%(n=9)。结论优化后的碘仿糊剂制备工艺简单,外观均匀细腻,润滑性好,便于进行乳牙根管充填。建立的碘仿含量测定方法准确、可靠,制剂质量可控。
[Abstract]:Objective to optimize the prescription of iodoform paste for root canal filling of deciduous teeth. Methods taking the fine degree of paste, lubricity, difficulty degree of root canal filling and removing difficulty degree as the inspection indexes, the multi-index comprehensive scoring method was used to screen the matrix types, and the prescription proportion was optimized by orthogonal design method. The content of iodoform in optimized prescription was determined by ultraviolet spectrophotometry. Results Dimethyl silicone oil was selected as the matrix of paste by multi-index comprehensive scoring method. The results of orthogonal test showed that the ratio of iodoform to zinc oxide was the main factor affecting the paste. The optimized formulation was as follows: the ratio of iodoform / zinc oxide was 3: 7, the proportion of clove oil was 1.5 and the ratio of powder to liquid was 70: 30. The linear equation for the determination of iodoform in the optimized formulation was A 6.781 3C-0.051 6(r=0.999 / 7, which indicated that the concentration of iodoform in 48.75 渭 g / L ~ (-1) of iodoform had a good linear relationship with the absorbance, and the average recovery was 99.83% (n ~ (9). Conclusion the optimized iodoform paste has the advantages of simple preparation, uniform appearance, good lubricity and convenient root canal filling. The established method is accurate, reliable and controllable in quality.
【作者单位】：北京大学口腔医学院口腔医院药剂科;北京大学口腔医学院口腔医院儿童口腔科;
【分类号】：R781.05

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