脱钙异体冻干骨联合富血小板衍生物治疗牙周骨内缺损疗效的Meta分析

发布时间：2018-05-18 04:35

本文选题：脱钙异体冻干骨 + 富血小板血浆　；参考：《华西口腔医学杂志》2017年06期

【摘要】：目的系统评价脱钙异体冻干骨(DFDBA)联合富血小板衍生物治疗牙周病导致的骨内缺损的有效性。方法在Pub Med、Web of Science、Embase、Cochrane Library、中国学术期刊网全文数据库等数据库中检索2016年5月之前发表的关于DFDBA联合富血小板衍生物治疗牙周病导致的骨内缺损的临床随机对照研究(RCT)。对纳入的文献研究进行质量评价。应用Rev Man 5.3软件进行Meta分析。结果 9篇RCT文献纳入Meta分析,共194例患者,303个位点。Meta分析结果显示:DFDBA联合富血小板衍生物试验组较对照组可以降低短期组(6个月)和长期组(12~18个月)的牙周袋探诊深度,均数差(MD)分别为0.75 mm[95%可信区间(CI)(0.31 mm,1.20 mm),P=0.001 0]、0.87 mm[95%CI(0.02 mm,1.72 mm),P=0.04];增加短期组(6个月)和长期组(12~18个月)的临床附着水平,MD分别为0.65 mm[95%CI(0.08 mm,1.22 mm),P=0.03]、1.31 mm[95%CI(0.60 mm,2.01 mm),P=0.000 3];减少长期组(12~18个月)的牙龈退缩[MD为-0.58 mm,95%CI(-0.78 mm,-0.38 mm),P0.000 01];增加短期组(6个月)和长期组(12~18个月)的骨充填高度,MD分别为0.52 mm[95%CI(0.03 mm,1.00 mm),P=0.04]、1.26 mm[95%CI(0.65 mm,1.86 mm),P=0.000 1]。结论 DFDBA联合富血小板衍生物能有效治疗牙周病导致的骨内缺损,效果优于单用组。但因为此次纳入研究较少,质量不高且样本量较小,所以仍需高质量的、大样本的RCT来进一步验证。
[Abstract]:Objective to evaluate the effectiveness of decalcified allogenic freeze-dried bone (DFDBA) combined with platelet rich derivatives in the treatment of intraosseous defects caused by periodontitis. Methods in the database of Pub Med, Web of Science, Embase, Cochrane Library, Chinese academic journal full text database, and other databases published before May 2016 on DFDBA combined with platelet rich derivatives A randomized controlled study (RCT) for the treatment of intraosseous defects caused by periodontitis. Quality evaluation of the included literature study. Meta analysis was carried out with Rev Man 5.3 software. Results 9 RCT literature included Meta analysis in 194 patients and 303 loci.Meta analysis showed that DFDBA combined with platelet rich test group was better than control group To reduce the depth of periodontal pocket detection in the short-term group (6 months) and the long-term group (12~18 months), the mean number difference (MD) was 0.75 mm[95% confidence interval (CI) (0.31 mm, 1.20 mm), P=0.001 0], 0.87 mm[95%CI (0.02 mm, 1.72 mm), P=0.04], and the clinical attachment level of the short-term group (6 months) and the long-term group (0.08, 0.08, 1, respectively). .22 mm), P=0.03], 1.31 mm[95%CI (0.60 mm, 2.01 mm), P=0.000 3]; reducing the gingival retraction of the long-term group (12~18 months) [MD for -0.58 mm, increases the bone filling height of the short-term group (6 months) and the long-term group (1, 1, 1), 1.26, 1.86, 1.86 P=0.000 1]. conclusion that DFDBA combined with platelet rich derivatives can effectively treat periodontal disease caused by intraosseous defects, which is better than the single use group. But because of the less study, low quality and small sample size, high quality and large sample RCT are still needed to further verify.
【作者单位】：遵义市正安县人民医院口腔科;重庆医科大学附属口腔医院牙体牙髓科;口腔疾病与生物医学重庆市重点实验室;重庆市高校市级口腔生物医学工程重点实验室;
【基金】：重庆市卫生局医学科研重点项目(2012-1-053)~~
【分类号】：R781.4

【相似文献】