早期愈合阶段牙种植体周沟液骨代谢相关因子的检测和种植体稳定性共振频率分析

发布时间：2018-05-27 07:23

本文选题：牙种植体 + 龈沟液　；参考：《北京大学学报(医学版)》2015年01期

【摘要】：目的:观察牙种植体周沟液中骨保护素(osteoprotegerin,OPG)、核因子κB受体活化因子配体(receptor activator of nuclear factor kappa B ligand,RANKL)在Straumann湟种植体骨愈合期的动态变化,结合种植体稳定性变化情况的共振频率分析,评价种植体周沟液和共振频率分析在监测种植体周围软组织健康状况和骨组织的改建更新过程中的作用。方法:35例牙齿缺失患者非潜入式植入Straumann湟种植体共35枚。在术中,术后1、2、3、4、6、8、12周,取相邻天然牙龈沟液和种植体周沟液,通过酶联免疫分析法检测样本中OPG及RANKL总量的变化情况,同时用共振频率分析仪检测各时间点的种植体稳定性数值(implant stability quotient,ISQ)。结果:术后2周时种植体的OPG水平显著高于术后4、6、8、12周时的水平,术后1周时种植体周沟液中的OPG/RANKL比值显著高于天然牙龈沟液中的OPG/RANKL比值。种植体ISQ值在术后前4周出现轻微波动,4周后开始上升,术后6周和8周的ISQ值显著高于植入后第1个月内的ISQ值,术后12周的ISQ值显著高于其他各测量时间点的ISQ值。结论:术后2周种植体周沟液OPG水平的升高反应可能与种植术后早期愈合阶段成骨细胞样细胞的增殖、分化和成骨活性的激发、增强有关。共振频率分析是一种评估种植体稳定性的安全、可靠、有效的方法,共振频率分析和种植体周沟液分析可以监测种植体周围软、硬组织变化,为判断种植体负重时机,分析临床远期预后提供依据。
[Abstract]:Objective: to observe the dynamic changes of osteoprotegerin (OPG) and nuclear factor- 魏 B receptor activating factor (activator of nuclear factor kappa B) ligand RANKLin osseoprotegerin osseous crevicular fluid (PDF) during bone healing in Straumann implants, and to analyze the resonance frequency of the stability of implants. To evaluate the role of periimplant drainage and resonance frequency analysis in monitoring the health status of the surrounding soft tissue and the regeneration of bone tissue. Methods 35 Straumann Huang implants were implanted in 35 cases of dental defect. During the operation, 12 weeks after operation, natural gingival crevicular fluid and periimplant crevicular fluid were taken from adjacent gingival crevicular fluid and periimplant crevicular fluid. The changes of total OPG and RANKL in the samples were detected by enzyme linked immunosorbent assay (Elisa). At the same time, the implant stability quotient was measured by resonance frequency analyzer. Results: the level of OPG in implant was significantly higher than that at 12 weeks after implantation, and the ratio of OPG/RANKL in periimplant crevicular fluid was significantly higher than that in natural gingival crevicular fluid 1 week after operation. The ISQ value of implant began to rise after 4 weeks of slight fluctuation. The ISQ value at 6 and 8 weeks after implantation was significantly higher than that in the first month after implantation, and the ISQ value at 12 weeks after implantation was significantly higher than that at other measured time points. Conclusion: the increase of OPG level in periimplant crevicular fluid 2 weeks after implantation may be related to the proliferation, differentiation and stimulation of osteogenic activity of osteoblast like cells in early healing stage after implantation. Resonance frequency analysis is a safe, reliable and effective method to evaluate implant stability. Resonance frequency analysis and periimplant ditch fluid analysis can monitor the changes of soft and hard tissue around the implant. To analyze the clinical long-term prognosis.
【作者单位】：北京大学口腔医学院·口腔医院牙周科;
【分类号】：R783.6

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