普萘洛尔与类固醇激素在治疗颌面部血管瘤的临床疗效对比研究的Meta分析

发布时间：2018-05-29 10:27

本文选题：婴幼儿血管瘤 + 普萘洛尔　；参考：《上海交通大学》2014年硕士论文

【摘要】：目的：目前对于普萘洛尔与类固醇激素治疗颌面部婴幼儿血管瘤（infantilehemangiomas，IHs）疗效与安全性的问题上仍存在争议。国内外已经有许多学者对于两种药物做过临床对比研究。本文旨在收集并总结相关文献，为临床合理用药提供询证医学证据。材料和方法：计算机检索Medline数据库、Pubmed数据库、Cochrane图书馆临床对照研究资料库及万方数据库、中国知网数据库。搜索国内外2013年9月以前发表的单纯应用普萘洛尔及单纯应用类固醇激素治疗血管瘤对照研究，对所纳入的研究提取有效数据，并运用Cochrane协作网提供的RevMan5.0软件对数据进行统计学分析。结果：按照已制定的检索策略，，纳入单纯应用普萘洛尔及单纯应用类固醇激素治疗血管瘤对照研究9篇。采用固定效应模型进行分析，结果显示普萘洛尔组在疗效方面优于类固醇激素组（RR=1.94,95%CI：1.40,2.69，P0.0001）差异有统计学意义。对药物不良反应做统计学分析，采用固定效应模型进行分析，结果显示普萘洛尔组在药物不良反应方面优于类固醇激素组（RR=0.42,95%CI：0.28，0.64，P0.0001）差异有统计学意义。在治疗IHs并发溃疡方面，暂无两类药物的随机对照研究，不过通过总结纳入的3篇普萘洛尔治疗IHs并发溃疡的研究，证明普萘洛尔较其他传统治疗方式，在治疗IHs并发溃疡方面有一定优势。结论：与单纯应用类固醇激素相比，普萘洛尔可以作为一线药物治疗婴幼儿血管瘤。
[Abstract]:Objective: to investigate the efficacy and safety of propranolol and steroid in the treatment of infantile hemangiomatosis (IHs) in infants with maxillofacial hemangioma. Many scholars at home and abroad have done clinical comparative research on the two drugs. The purpose of this paper is to collect and summarize the relevant literature and provide evidence for rational use of drugs in clinic. Materials and methods: the Medline database was searched by computer. To search for the control study on the treatment of hemangioma with propranolol alone and steroid hormone alone published before September 2013, and to extract valid data from the included study, The data are analyzed statistically by using RevMan5.0 software provided by Cochrane Cooperative Network. Results: according to the search strategy, 9 articles were included in the control study of propranolol alone and steroid hormone alone in the treatment of hemangioma. The results showed that the effect of propranolol group was better than that of steroid hormone group. The adverse drug reactions were analyzed statistically and the fixed effect model was used. The results showed that the propranolol group was better than the steroid hormone group in the adverse drug reaction. The difference was statistically significant (P 0.0001). In the treatment of IHs with ulcers, there is no randomized controlled study of two kinds of drugs. However, by summarizing the three studies of propranolol in the treatment of IHs complicated with ulcers, it is proved that propranolol is more effective than other traditional treatment methods. It has some advantages in the treatment of IHs complicated with ulcers. Conclusion: propranolol can be used as a first-line drug in the treatment of infantile hemangioma.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R739.81

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