生长因子复合支架材料在即刻种植周围骨缺损中的作用

发布时间：2018-05-29 13:55

本文选题：神经生长因子 + 支架　；参考：《中国组织工程研究》2017年02期

【摘要】：背景:研究发现神经生长因子在骨的愈合过程中发挥重要作用,但关于生长因子复合支架材料在犬即刻种植周围骨缺损中作用的研究不多。目的:分析神经生长因子复合支架材料在犬即刻种植周围骨缺损中的作用。方法:制备神经生长因子复合锶磷灰石支架材料,建立犬下颌骨缺损动物模型,将犬下颌骨缺损种植体分为实验组、阳性对照组和空白对照组,实验组植入神经生长因子复合锶磷灰石;阳性对照组植入锶磷灰石;空白对照组不植入任何材料。观察3组犬下颌骨种植体周围骨缺损的CT三维图像重建情况和苏木精-伊红染色情况。结果与结论:1空白对照组犬骨缺损中央没有新骨生成,周围有少量新生骨生成;阳性对照组和实验组犬骨缺损处骨小梁从中间向四周扩散形成骨修复;2实验组犬下颌骨种植体周围骨小梁的骨密度、数量、厚度、种植体-骨结合率均高于阳性对照组和空白对照组(P0.05),阳性对照组4项指标高于空白对照组(P0.05);实验组犬下颌骨种植体周围骨小梁分离度低于阳性对照组和空白对照组(P0.05),阳性对照组低于空白对照组(P0.05);3苏木精-伊红染色显示,实验组犬下颌骨种植体支架网孔中有大量新骨生成,骨小梁排列整齐,周围骨质和新生组织连接紧密;阳性对照组犬下颌骨可见新生类骨质和骨小梁,以及少量死骨碎片;空白对照组骨缺损处有部分新骨生成,骨小梁排列不整齐,周围骨质和新生组织连接不紧密;4结果表明,神经生长因子复合支架材料能够促进犬即刻种植周围骨缺损的骨生成,是一种比较好的骨修复材料。
[Abstract]:Background: studies have found that neural growth factors play an important role in the healing process of bone, but there are few studies on the role of growth factor composite scaffold in the immediate implantation of bone defects in dogs. Objective: to analyze the role of neural growth factor composite scaffold in the immediate implantation of circumference bone defects in dogs. Factor compound strontium apatite scaffold material was used to establish the animal model of canine mandible defect. The canine mandible defect implants were divided into experimental group, positive control group and blank control group. The experimental group was implanted with SR apatite with nerve growth factor, and the positive control group was implanted strontium apatite, and the blank control group was not implanted any material. The 3 groups of canine mandibles were observed. The reconstruction of CT three-dimensional image of bone defect around the implant and the condition of hematoxylin eosin staining. Results and conclusion: 1 in the blank control group, there was no new bone formation in the center of the canine bone defect, and a small amount of new bone formation was found around the bone. The bone trabecula diffused from the middle to the periphery to form bone repair in the positive control group and the experimental group, and the 2 experimental group of canine mandible bone. The bone density, quantity, thickness and implant bone binding rate around the implant were higher than that in the positive control group and the blank control group (P0.05), and the 4 indexes in the positive control group were higher than that of the blank control group (P0.05). The separation degree of the bone trabecula around the canine mandible implants was lower than that of the positive control group and the blank control group (P0.05), and the positive control group was lower than the positive control group. In the blank control group (P0.05), 3 hematoxylin eosin staining showed that there were a large number of new bone formation in the experimental group of canine mandible implant scaffold. The bone trabecula was arranged neatly and the surrounding bone and the new tissue were closely connected. The new bone and bone trabecula and a small amount of dead bone fragments were found in the mandible of the positive control group, and the blank control group had a bone defect. Part of the new bone formation, bone trabecular arrangement is not neat, the surrounding bone and the new tissue are not closely connected. 4 the results show that the nerve growth factor composite scaffold material can promote the bone formation of the canine immediate implant bone defect, and it is a better bone repair material.
【作者单位】：河北省人民医院口腔科;河北省人民医院公费医保办;
【分类号】：R318

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