饮酒和细胞外超氧化物岐化酶、乙醛脱氢酶2基因多态性与口腔鳞状细胞癌的相关性研究

发布时间：2018-05-31 10:47

本文选题：口腔鳞状细胞癌 + 细胞外超氧化物岐化酶　；参考：《华西口腔医学杂志》2014年02期

【摘要】：目的探讨饮酒和细胞外超氧化物岐化酶(EC-SOD)、乙醛脱氢酶2(ALDH2)基因多态性与口腔鳞状细胞癌患病之间的关系。方法采用病例对照研究的方法,以750例口腔鳞状细胞癌患者(病例组)及750例非癌对照者(对照组)的外周血白细胞为样本,采用聚合酶链反应(PCR)技术分析EC-SOD和ALDH2基因的多态性,并分析该基因多态性与口腔鳞状细胞癌患病的关系。结果病例组EC-SOD(C/G)和ALDH2变异基因型频率分别为38.27%、69.47%,对照组则为21.07%、44.40%,二者差异有统计学意义(P0.01)。EC-SOD(C/G)患口腔鳞状细胞癌的风险显著增加(OR=2.32),ALDH2变异基因型的患病风险也显著增加(OR=2.85)。基因突变的协同分析发现,EC-SOD(C/G)/ALDH2变异基因型在病例组和对照组中的分布频率分别为30.67%和6.80%,二者差异有统计学意义(P0.01)。EC-SOD(C/G)/ALDH2变异基因型患口腔鳞状细胞癌的风险显著增加(OR=8.13)。病例组的饮酒率明显高于对照组(OR=2.70),EC-SOD(C/G)及ALDH2变异基因型与饮酒有协同作用(OR=25.00)。结论 ECSOD及ALDH2变异基因型和饮酒是口腔鳞状细胞癌的易患因素,三者联合在口腔鳞状细胞癌的发生中有协同作用。
[Abstract]:Objective to investigate the relationship between alcohol consumption, extracellular superoxide dismutase (EC-SOD), acetaldehyde dehydrogenase (ALDH2) gene polymorphism and oral squamous cell carcinoma (OSCC). Methods Peripheral blood leukocytes were collected from 750 patients with oral squamous cell carcinoma (SCC) and 750 non-cancerous controls (control group) by a case-control study. Polymerase chain reaction (PCR) technique was used to analyze the polymorphism of EC-SOD and ALDH2 gene, and the relationship between the polymorphism and the prevalence of oral squamous cell carcinoma. Results the genotype frequencies of EC-SODN C / G) and ALDH2 were 38.27 and 21.07 respectively in the case group and 44.40 in the control group. There was a significant difference between the two groups in the risk of oral squamous cell carcinoma (OSCC). The risk of OR2.32ALDH2 variant genotype was also significantly increased. The co-analysis of gene mutation showed that the distribution frequency of the genotype of EC-SODG / ALDH2 mutation was 30.67% and 6.80 in the case group and the control group, respectively. There was a significant difference between the two genotypes. The risk of oral squamous cell carcinoma was significantly increased by the genotype of the C- SODX / C / Gr / ALDH2 mutation in the patients with oral squamous cell carcinoma (OSCC), and the risk of oral squamous cell carcinoma (OSCC) was significantly higher than that in the control group (P < 0.05). The drinking rate in the case group was significantly higher than that in the control group (2.70 EC-SOD C / G) and the genotype of ALDH2 mutation had a synergistic effect on alcohol consumption. Conclusion ECSOD and ALDH2 genotypes and alcohol consumption are the predisposing factors of oral squamous cell carcinoma, and there is a synergistic effect among them in the occurrence of oral squamous cell carcinoma.
【作者单位】：新乡医学院第一附属医院消化内科;新乡医学院第一附属医院口腔科;
【分类号】：R739.85

【共引文献】