S100A7蛋白在口腔黏膜下纤维性变治疗前后组织中的表达

发布时间：2018-05-31 15:35

本文选题：SA + 口腔黏膜纤维性变　；参考：《国际口腔医学杂志》2015年05期

【摘要】：目的观察口腔黏膜下纤维性变(OSF)患者治疗前后的颊黏膜和正常颊黏膜中S100A7的表达。方法收集10例正常颊黏膜组织和10例OSF患者经丹参联合小剂量曲安奈德局部注射治疗前后的颊黏膜组织,用免疫组织化学方法检测其S100A7的表达,比较并分析其表达差异。结果 1)治疗后OSF患者S100A7的阳性率为30%,表达量计分为(2.30±0.82)分,均低于治疗前的阳性率(90%)和表达量计分值(4.20±1.14)分,且差异有统计学意义(P0.05)。2)治疗后OSF患者和正常黏膜的S100A7阳性率分别为30%、0,差异无统计学意义(P0.05);但OSF治疗后S100A7的表达量计分值(2.30±0.82)分,高于正常黏膜的表达量计分(0.60±0.52)分,差异有统计学意义(P0.05)。结论丹参联合小剂量曲安奈德局部注射治疗OSF能下调S100A7的表达,且S100A7可作为评价OSF疗效的指标之一。
[Abstract]:Objective to observe the expression of S100A7 in buccal mucosa and normal buccal mucosa of patients with oral submucous fibrosis before and after treatment. Methods 10 cases of normal buccal mucosa and 10 cases of OSF were collected before and after local injection of Salvia miltiorrhiza and triamcinolone acetonide. The expression of S100A7 was detected by immunohistochemical method. Results 1) after treatment, the positive rate of S100A7 in OSF patients was 30. The positive rate of expression meter was 2.30 卤0.82, which was lower than the positive rate of 90% and the score of expression meter was 4.20 卤1.14). The positive rates of S100A7 in patients with OSF and normal mucosa were 30 / 0, respectively, but the positive rate of S100A7 expression was 2.30 卤0.82after OSF treatment, which was higher than that of normal mucosa (0.60 卤0.52). The difference was statistically significant (P 0.05). Conclusion Salvia miltiorrhiza combined with low dose triamcinolone acetonide injection can down-regulate the expression of S100A7 and S100A7 can be used as an index to evaluate the curative effect of OSF.
【作者单位】：中南大学湘雅医院口腔科;解放军163医院病理科;
【基金】：湖南省科技厅科技计划一般项目(2013SK3024)
【分类号】：R781.5

【参考文献】