全身与局部用药在预防种植牙术后感染中的临床研究

发布时间：2018-06-01 09:10

本文选题：盐酸米诺环素 + 甲硝唑　；参考：《中华医院感染学杂志》2014年01期

【摘要】：目的比较分别采用全身用药和局部用药在预防种植牙术后发生感染的效果,为合理使用抗菌药物提供依据。方法选择自2008年8月-2013年8月因牙列缺损行牙种植术的患者共162例,随机分为全身组与局部组各81例,所有患者均采用ITI种植系统,全身组给予口服罗红霉素联合奥硝唑,局部组在种植体周围及切口内局部给予盐酸米诺环素联合甲硝唑,观察两组患者术后疼痛的发生情况以及用药效果。结果全身组术后完全无疼痛感的有41例占50.62%,局部组患者术后完全无疼痛感的有53例占65.43%,全身组术后完全无疼痛感的患者明显低于局部组(χ2=3.650,P0.05);疼痛程度组间比较,局部组明显优于全身组(Z=-0.182,P0.05);全身组的显效率为67.90%,局部组的显效率为85.19%,局部组的显效率明显高于全身组(χ2=6.739,P0.05)。结论在牙种植术后采用局部应用盐酸米诺环素联合甲硝唑预防感染的效果优于全身用药,值得临床推广。
[Abstract]:Objective to compare the efficacy of systemic and local administration in preventing infection after dental implants, so as to provide evidence for rational use of antimicrobial agents. Methods from August 2008 to August 2013, 162 patients with dental implant were randomly divided into two groups: the systemic group (n = 81) and the local group (n = 81). All the patients were treated with ITI implantation system, and the patients in the whole body group were treated with roxithromycin and ornidazole orally. The local group was given minocycline hydrochloride and metronidazole locally around implants and incisions to observe the incidence of postoperative pain and the effect of medication in the two groups. Results there were 41 cases (50.62) in the whole body group and 53 cases (65.43%) in the local group without pain after operation. The patients in the whole body group were significantly lower than those in the local group (蠂 ~ (2) 3.650) P 0.05 (蠂 ~ (2) 2.650), the pain degree was compared between the two groups, and there was no pain in the whole body group (蠂 ~ (2) 3.650) (P < 0.05). The effective rate of local group was 67.90, that of local group was 85.19, and that of local group was significantly higher than that of whole body group (蠂 2 6.739 P 0.05). Conclusion Local application of minocycline hydrochloride combined with metronidazole in prevention of infection after dental implantation is more effective than systemic administration, and it is worth popularizing.
【作者单位】：浙江中医药大学附属第三医院口腔科;
【基金】：浙江省科技厅基金项目(2013C332430) 浙江省医药卫生科技计划基金项目(2012kyb143)
【分类号】：R783

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