掺镁羟基磷灰石涂层对种植体骨结合的影响

发布时间：2018-06-01 10:41

本文选题：种植体 + 掺镁羟基磷灰石(Mg-HA)　；参考：《口腔医学》2014年04期

【摘要】：目的用荧光显微镜分析掺镁羟基磷灰石涂层对种植体骨结合的影响。方法将20个种植体分为2组,每组10个。一组为掺镁羟基磷灰石(magnesium-substituted hydroxyapatite,Mg-HA)涂层种植体;一组为纯羟基磷灰石(hydroxyapatite,HA)涂层种植体。涂层均采用电化学沉积技术制备。种植体植入成年兔股骨内。在种植术后第7天给予盐酸土霉素;在术后第28天给予茜素氨羧络合剂;在术后第46天给予钙黄绿素。8周后取出股骨,制备硬组织切片,然后行荧光显微观察,分析两组种植体表面的骨沉积率(bone mineral apposition rate,MAR)、骨面积率(bone area ratio,BAR)、骨接触率(bone to implant contact,BIC)是否存在差异。结果荧光显微观察显示两组种植体周围均有广泛新骨形成。种植术后第7天至53天,Mg-HA组的MAR、BAR大于HA组,但两者间无显著差异(P0.05)。术后第7天和第28天,Mg-HA组的BIC大于HA组,两者间有显著差异(P0.05)。结论与HA涂层相比,Mg-HA涂层可促进种植体的早期骨结合。
[Abstract]:Objective to analyze the effect of mg-doped hydroxyapatite coating on bone bonding of implant by fluorescence microscope. Methods 20 implants were divided into 2 groups, 10 in each group. One group was coated with magnesium-doped hydroxyapatite (Mg-HA) and the other was coated with hydroxyapatite HA (pure hydroxyapatite). The coatings were prepared by electrochemical deposition. Implants were implanted into the femur of adult rabbits. On the 7th day after implantation, oxytetracycline hydrochloride was given; on the 28th day after implantation, alizarin carboxyl complex was given; on the 46th day after implantation, the femur was taken out of the femur, and the hard tissue sections were prepared, and fluorescence microscopy was performed. The difference of bone mineral apposition rate, bone area ratio and bone contact rate (bone to implant contactbone) between the two groups were analyzed. Results fluorescence microscopy showed extensive new bone formation around implants in both groups. From the 7th to the 53rd day after implantation, the MARBAR in the Mg-HA group was higher than that in the HA group, but there was no significant difference between the two groups (P 0.05). The BIC of Mg-HA group was higher than that of HA group on the 7th and 28th day after operation, and there was a significant difference between the two groups (P 0.05). Conclusion compared with HA coating, Mg-HA coating can promote the early bone bonding of implants.
【作者单位】：浙江大学医学院附属口腔医院种植科;浙江中医药大学口腔医学院;杭州口腔医院城西分院综合科;
【基金】：浙江省自然科学基金杰青项目(R2110374)
【分类号】：R783.6

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