Mimics与Micro-CT内置软件测量小鼠颅骨缺损骨再生的对比研究

发布时间：2018-06-01 12:20

本文选题：活体显微CT + 颅骨缺损　；参考：《重庆医科大学学报》2015年02期

【摘要】：目的:对比分析Mimics软件与显微-CT(Micro-computed tomography,Micro-CT)内置分析软件对颅骨缺损内新生骨量及骨愈合率的测量结果,评价2种测量方法的差异性。方法:在小鼠右侧颅顶骨制备直径4 mm圆形骨缺损,分别于术后当天、6周、12周,对小鼠颅骨进行活体Micro-CT扫描,然后利用Micro-CT扫描仪内置软件重建颅骨缺损的三维图像并测量缺损内新生骨体积及愈合率,且利用Mimics软件对Micro-CT扫描的二维图片进行三维重建,并测量缺损内新生骨体积及愈合率。结果:与术后6周相比,术后12周Micro-CT扫描仪内置软件和Mimics软件测量的缺损内新生骨体积和骨愈合率均增加,差异有统计学意义(P0.05);术后6周和12周,Mimics软件的测量结果与Micro-CT扫描仪内置软件测量的颅骨缺损内新骨体积及骨愈合率相比,差异无统计学意义(P0.05)。结论:缺损术后6周和术后12周,Mimics软件对Micro-CT扫描后的二维图片进行重建并计算出的颅骨缺损新生骨体积及骨愈合率,与Micro-CT扫描仪内置软件的测量结果均一致,且测量方法更简单。
[Abstract]:Objective: to compare and analyze the measurement results of bone mass and bone healing rate in cranial defect by Mimics software and Micro-CTT micro-computed tomography micro-CT software, and to evaluate the difference between the two measurement methods. Methods: the right cranioparietal bone was used to prepare 4 mm round bone defect. The bone was scanned with Micro-CT in vivo at 6 weeks and 12 weeks after operation. Then the 3D image of skull defect was reconstructed by Micro-CT scanner and the new bone volume and healing rate were measured. The 2D image of Micro-CT scan was reconstructed by Mimics software and the volume and healing rate of new bone in defect were measured. Results: compared with 6 weeks after operation, the volume of new bone and the rate of bone healing were increased 12 weeks after operation measured by Micro-CT scanner software and Mimics software. The difference was statistically significant (P 0.05), but there was no significant difference between the new bone volume and bone healing rate in the skull defect measured by Micro-CT software at 6 and 12 weeks after operation. Conclusion: the volume of new bone and the rate of bone healing of the skull defect were calculated by the reconstruction of two-dimensional images after Micro-CT scanning by the software of imics at 6 weeks and 12 weeks after operation, which are in agreement with the measurement results of the software built in the Micro-CT scanner. And the measurement method is simpler.
【作者单位】：重庆医科大学附属口腔医院修复科;口腔疾病与生物医学重庆市重点实验室;
【基金】：国家自然科学基金面上资助项目(编号:81200767/H1402) 重庆市卫生局资助项目(编号:2012-2-8)
【分类号】：R782.2

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