消溃散联合复方甲硝唑漱口液治疗乳腺癌患者口服依维莫司所致口腔溃疡的临床研究

发布时间：2018-06-02 21:03

本文选题：消溃散 + 复方甲硝唑漱口液　；参考：《中国中西医结合杂志》2017年11期

【摘要】：目的观察消溃散联合复方甲硝唑漱口液治疗依维莫司所致口腔溃疡的临床治疗效果。方法按照随机数字表法将30例口服依维莫司后出现口腔溃疡的乳腺癌患者随机分为治疗组和对照组,每组15例。对照组患者给予复方甲硝唑漱口液漱口,治疗组在此基础上给予消溃散外用,从出现口腔溃疡后24h开始用药,用药第1、3、5天进行溃疡面观察以及疼痛评分。记录所有患者口腔溃疡的治疗有效率、疼痛缓解程度、疼痛评分及溃疡愈合时间。结果治疗组口腔溃疡有效率为85.7%(12/14)高于对照组64.3%(9/14,P0.05);治疗组疼痛缓解率[100.0%(14/14)]明显高于对照组[64.3%(9/14),P0.05];与本组治疗前比较,对照组治疗后5天、治疗组治疗后3、5天疼痛评分降低(P0.05)。与对照组比较,治疗后3、5天治疗组疼痛评分明显降低(P0.05)。治疗组溃疡愈合时间(4.5±1.7)d短于对照组(7.2±2.3)d(P0.05)。结论消溃散联合复方甲硝唑漱口液治疗依维莫司所致口腔溃疡能有效缓解疼痛程度,加快溃疡愈合时间。
[Abstract]:Objective to observe the clinical effect of Xiaoshusan combined with compound metronidazole gargle in the treatment of oral ulcer induced by ivermosine. Methods 30 patients with oral ulcer after oral administration were randomly divided into treatment group and control group with 15 cases in each group. The patients in the control group were given compound metronidazole gargle and the treatment group was given external application of Xiaozhousan on this basis. The drug was used 24 hours after the onset of oral ulcer. The ulcer surface was observed and the pain score was scored on the 5th day after the treatment. The effective rate, pain relief, pain score and healing time of all patients with oral ulcer were recorded. Results the effective rate of oral ulcer in the treatment group was 85.7% / 14) higher than that in the control group (64.3% 14 / 14), and the pain relief rate in the treatment group [100.030% 14 / 14] was significantly higher than that in the control group [64.3% 9 / 14% P 0.05]. Compared with the control group, the pain score of the treatment group was significantly lower than that of the control group 3 days after treatment. The healing time of ulcer in the treatment group was 4.5 卤1.7 days shorter than that in the control group. Conclusion Xiaoliu Powder combined with compound metronidazole gargle can effectively relieve the pain and accelerate the healing time of oral ulcer caused by ivermosone.
【作者单位】：江南大学附属医院(无锡市第四人民医院)中西医肿瘤科;江苏省无锡市查桥社区卫生服务中心内科;
【基金】：江苏省无锡市医管中心项目(No.YGZXM1403)
【分类号】：R737.9;R781.5

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