精氨酸牙膏对釉质早期龋再矿化作用的研究

发布时间：2018-06-05 11:26

本文选题：釉质早期龋 + 精氨酸牙膏　；参考：《华西口腔医学杂志》2014年01期

【摘要】：目的研究精氨酸牙膏对人牙釉质早期龋的再矿化效果。方法制备人牙釉质龋标本,随机分为3组:空白组(去离子水处理),对照组(普通市售含氟牙膏处理,含质量分数0.14%单氟磷酸钠),实验组(精氨酸牙膏处理,含质量分数0.14%单氟磷酸钠和8%精氨酸)。经体外pH循环10 d,测量pH循环前后各组样本的表面显微硬度,计算其差值;并通过偏光显微镜观察各组样本再矿化前后的形态学改变。pH循环结束后,脱矿处理2 h,测量其表面显微硬度,计算与pH循环前的差值,评估再矿化处理对釉质抗酸能力的影响。采用酸蚀法测定各组的氟摄入量。结果与对照组和空白组比较,实验组釉质表面的显微硬度、抗酸能力,以及氟摄入量均明显升高。偏光显微镜下观察,实验组病损深度明显变浅,且有表层下再矿化条带,而空白组与对照组病损无明显变化。结论精氨酸牙膏能有效促进人牙釉质龋表层及表层下再矿化,在早期龋的防治领域具有较大的临床应用前景。
[Abstract]:Objective to study the effect of arginine toothpaste on early caries of human enamel. Methods Human enamel caries were prepared and randomly divided into three groups: blank group (treated with deionized water), control group (treated with fluoride toothpaste, 0.14% sodium monofluorophosphate by mass fraction) and experimental group (treated with arginine toothpaste). It contains 0.14% sodium monofluorophosphate and 8% arginine. After 10 days of extracorporeal pH circulation, the surface microhardness of each group was measured before and after pH cycling, and the difference was calculated, and the morphological changes before and after remineralization were observed by polarizing microscope. The surface microhardness of demineralized enamel was measured for 2 h, the difference with pH before cycling was calculated, and the effect of remineralization on the acid resistance of enamel was evaluated. Fluorine intake was determined by acid etching method. Results compared with the control group and the blank group, the microhardness, acid resistance and fluoride intake of the enamel surface in the experimental group were significantly increased. Under the polarizing microscope, the depth of the lesion in the experimental group was obviously shallower, and there was a strip of mineralization under the surface layer, but there was no obvious change in the lesion in the blank group and the control group. Conclusion Arginine toothpaste can effectively promote the surface and subsurface mineralization of human enamel caries and has a great clinical application prospect in the field of prevention and treatment of early caries.
【作者单位】：口腔疾病研究国家重点实验室华西口腔医院牙体牙髓病科(四川大学);
【基金】：四川省科技厅口腔转化医学共用平台基金资助项目(JC-PT2011-9) 科技部“973计划”前期研究专项课题基金资助项目(2011CB512108)
【分类号】：R781.1

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