应用非刺激性全唾液法对脂代谢紊乱患者行种植义齿预后疗效的短期分析

发布时间：2018-06-08 12:27

本文选题：脂代谢紊乱 + 种植体　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:研究脂代谢紊乱的牙列缺损患者行种植义齿修复后牙周及种植体周的检查、唾液中炎性因子表达、细菌的相对量和种植体稳定性,分析脂代谢紊乱患者的种植预后状况。方法:将脂代谢紊乱的牙列缺损患者设为实验组,血脂健康的牙列缺损患者设为对照组,在种植前,种植后4周、12周、24周收集患者唾液,ELISA方法检测唾液中的白细胞介素6(IL-6)、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)表达,RT-PCR检测牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)、福赛斯坦纳菌(Tannerella forsythia,TF)、具核梭杆菌(Fusobacterium nucleatum,Fn)的相对量,Osstell ISQTM共振频率无线分析仪检测种植体的稳定性,并用Florida探针检测牙周状况。结果:2组的种植后探诊深度(PD)、出血指数(BI)、共振频率无线分析仪检测种植体稳定性数ISQ值无统计学差异(P0.05)。各组种植前,种植后4周、12周ISQ值、IL-6、IL-1β、TNF-α表达比较差异有统计学意义(P0.05)。种植前实验组IL-6、IL-1β、TNF-α的表达高于对照组(P0.05);而种植后24周实验组与对照组种植前IL-6、IL-1β、TNF-α的表达无统计学差异(P0.05)。Pg、Tf、Td、Fn相对SQ值四次检查结果逐渐减少,差异有统计学意义(P0.05),Td相对SQ值四次检查结果无差异(P0.05),实验组和对照组Pg、Tf、Fn、Td相对SQ值结果无差异(P0.05)。结论:种植术后脂代谢紊乱患者同血脂健康者一样有良好的种植体稳定性,即脂代谢紊乱患者同样可以取得良好的种植预后。
[Abstract]:Objective: to study the periodontal and periimplant periodontal examination, the expression of inflammatory factors in saliva, the relative quantity of bacteria and the stability of implant in patients with dyslipidemic dentition, and to analyze the prognosis of implant in patients with dyslipidemia. Methods: the patients with dyslipidemia were divided into experimental group and control group. Detection of Interleukin-6, IL-1 尾, TNF- 伪 expression in saliva by Elisa for detecting Porphyromonas gingivalis PgG, Tannerella forsythia TFN, Clostridium gingivalis by RT-PCR The relative quantity of Fusobacterium nucleatum Fn. was used to detect the stability of implants by Osstell ISQTM resonance frequency wireless analyzer. Periodontal status was detected with Florida probe. Results there was no significant difference in the number of ISQ between the two groups (P 0.05), such as the depth of probe after implantation, the bleeding index and the index of BII. The ISQ of implant stability was not significantly different from that of the control group (P < 0.05). Before and 4 weeks after implantation, the ISQ value and the expression of IL-1 尾 -TNF- 伪 were significantly higher in each group than in the control group (P 0.05). The expression of IL-6, IL-1 尾 and TNF- 伪 in the experimental group was higher than that in the control group before implantation, but there was no significant difference in the expression of IL-6, IL-1 尾 and TNF- 伪 between the experimental group and the control group 24 weeks after implantation. There was no significant difference in the four times of P0.05Td relative sq value between the experimental group and the control group, but there was no difference between the experimental group and the control group. Conclusion: the patients with dyslipidemia after implantation have the same good implant stability as those with healthy blood lipids, that is, the patients with dyslipidemia can also obtain a good prognosis of implantation.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R783.6

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