翻瓣术对老年重度牙周炎冠心病患者血清TNF-α、IL-6和CRP水平的影响

发布时间：2018-06-10 14:16

本文选题：重度牙周炎 + 冠心病　；参考：《重庆医学》2015年06期

【摘要】：目的探讨老年冠心病伴重度牙周炎患者不同牙周治疗后,牙周状况及血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)和C反应蛋白(CRP)的变化。方法将90例伴有重度牙周炎的老年冠心病患者分为3组,每组30例,对照组仅进行冠心病治疗,基础组在冠心病治疗基础上进行牙周基础治疗,联合组患者在冠心病治疗基础上进行牙周基础治疗和翻瓣术,比较3组各观察指标的差异。结果联合组和基础组经牙周基础治疗后,牙周袋深度(PD)、龈沟出血指数(SBI)、斑指数(PLI)、探诊深度、探诊出血均明显下降(P0.05),并有显著的附着获得(P0.05);联合组与基础组治疗后比较,PD、SBI、临床附着丧失(CAL)、探诊深度、探诊出血差异有统计学意义(P0.05)。治疗后,联合组和基础组TNF-α、IL-6及CRP水平较对照组明显降低(P0.05);基础组和联合组治疗后血清中TNF-α、IL-6及CRP水平比较,差异有统计学意义(P0.05)。结论牙周治疗和翻瓣术均能降低老年冠心病患者相关血清炎性因子TNF-α、IL-6和CRP水平,但相对于牙周基础治疗,翻瓣术效果更佳。
[Abstract]:Objective to investigate the changes of periodontal status and serum tumor necrosis factor TNF- 伪 (TNF- 伪), interleukin-6 (IL-6) and C-reactive protein (CRP) in elderly patients with coronary heart disease (CHD) and severe periodontitis after different periodontal treatments. Methods 90 elderly patients with severe periodontitis were divided into 3 groups, 30 cases in each group. The control group was treated with coronary heart disease only, and the basic group was treated with periodontal basic therapy on the basis of coronary heart disease. The patients in the combined group were treated with periodontal basic therapy and valvus operation on the basis of coronary heart disease, and the differences of the observed indexes among the three groups were compared. Results after periodontal basic treatment, the periodontal pocket depth, gingival sulcus bleeding index, plaque index and probing depth were observed in the combined group and the basic group. Compared with the basic group, the clinical attachment loss of CALI, the depth of probing and the difference of the bleeding between the combined group and the basic group were statistically significant (P 0.05). After treatment, the levels of TNF- 伪 IL-6 and CRP in the combined group and the basic group were significantly lower than those in the control group, while the serum levels of TNF- 伪 IL-6 and CRP in the basic group and the combined group were significantly lower than those in the control group (P 0.05). Conclusion both periodontal therapy and valvuloplasty can decrease the levels of TNF- 伪 IL-6 and CRP in serum of elderly patients with coronary heart disease, but the effect of valvulation is better than that of basic periodontal therapy.
【作者单位】：泸州医学院附属口腔医院口腔内科;泸州医学院免疫教研室;
【分类号】：R781.4

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