盐酸米诺环素原位凝胶的制备及其对牙周炎大鼠的治疗效果

发布时间：2018-06-13 14:44

本文选题：牙周炎 + 盐酸米诺环素　；参考：《国际药学研究杂志》2017年04期

【摘要】：目的评价盐酸米诺环素原位凝胶对牙周炎大鼠的治疗效果。方法结扎/高糖饮食/局部接种牙龈卟啉单胞菌/肌肉注射醋酸泼尼松龙联合因素建立牙周炎大鼠模型,4周后根据临床检查和病理切片确定牙周炎模型是否建立成功。将28只牙周炎模型大鼠分为4组:模型组、阳性对照药(盐酸米诺环素软膏,派丽奥)组、自制空白凝胶组和自制盐酸米诺环素原位凝胶组,分别在治疗前和治疗后4周检查牙龈指数、出血指数、探诊出血和探诊深度4项临床指标。结果牙周炎大鼠经盐酸米诺环素软膏和盐酸米诺环素原位凝胶治疗后,牙周组织炎症程度及牙周破坏程度比模型组和空白凝胶组减轻。结论盐酸米诺环素原位凝胶治疗大鼠牙周炎疗效明显,有望成为一种新型牙周炎治疗制剂。
[Abstract]:Objective to evaluate the therapeutic effect of minocycline hydrochloride in situ gel on periodontitis rats. Methods the rat model of periodontitis was established by ligation / high-glucose diet / local inoculation of porphyromonas gingivalis / intramuscular injection of prednisolone acetate for 4 weeks. Twenty-eight rats with periodontitis were divided into four groups: model group, positive control group (minocycline hydrochloride ointment, Pelio group), self-made blank gel group and self-made minocycline hydrochloride in-situ gel group. Gingival index, bleeding index, probing bleeding and probing depth were examined before and 4 weeks after treatment. Results after treated with minocycline hydrochloride ointment and minocycline hydrochloride in situ gel, the degree of periodontal inflammation and periodontal destruction in rats with periodontitis was less than that in model group and blank gel group. Conclusion Minocycline hydrochloride in situ gel is an effective treatment for periodontitis in rats, and it is expected to be a new kind of periodontitis therapy.
【作者单位】：黑龙江省佳木斯大学口腔医学院;军事医学科学院放射与辐射医学研究所;军事医学科学院附属医院口腔科;山东中医药大学药学院;
【基金】：解放军第307医院转化医学资助项目(ZH-2014-05)
【分类号】：R781.42

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