拔牙位点保存用复合温敏凝胶的构建及体外表征

发布时间：2018-06-18 11:37

本文选题：位点保存 + 壳聚糖　；参考：《口腔医学研究》2017年01期

【摘要】：目的:制备多壁碳纳米管/羟基磷灰石/壳聚糖复合温敏凝胶,探讨其作为拔牙位点保存材料的理化性能。方法:采用原位沉积方法制备多壁碳纳米管/羟基磷灰石(MWNT/HA简称HAC)复合无机材料,将其分散至壳聚糖温敏凝胶中,制备壳聚糖/多壁碳纳米管/羟基磷灰石(CS/MWNT/HA简称CS/HAC)复合温敏凝胶,以成胶时间、孔径、孔隙率、机械强度及降解性能为指标优化配方设计,并表征复合温敏凝胶的微观形貌及理化性能。结果:以10g/L的HAC作为补强成分加入到壳聚糖溶液中,能够在不影响成胶并保证一定孔隙率(84%)的前提下,提高材料的机械性能(抗压强度0.441MPa),所获复合温敏凝胶具有适宜的临床操作时间(12min),并具有可控的降解速率。结论:负载HAC的复合温敏凝胶具有良好的成型性,并具有较好的机械性能,在拔牙位点保存领域具有良好的应用前景。
[Abstract]:Aim: to prepare multi-walled carbon nanotubes / hydroxyapatite / chitosan composite thermosensitive gels and to investigate their physical and chemical properties as preservation materials for extraction sites. Methods: multiwalled carbon nanotubes / hydroxyapatite / MWNT / HA composite inorganic materials were prepared by in-situ deposition and dispersed into chitosan thermosensitive gel. Chitosan / multiwalled carbon nanotubes / hydroxyapatite composite thermo-sensitive gels were prepared. The optimized formulation was based on gelation time, pore size, porosity, mechanical strength and degradation performance. The microstructure and physicochemical properties of the composite thermo-sensitive gel were also characterized. Results: adding 10 g / L HAC as a reinforcing component into chitosan solution can ensure a certain porosity without affecting gelation. By improving the mechanical properties (compressive strength of 0.441MPA), the composite thermosensitive gel has a suitable clinical operation time of 12 min and a controllable degradation rate. Conclusion: the composite thermosensitive gel loaded with HAC has good formability and good mechanical properties, and has a good application prospect in the field of tooth extraction site preservation.
【作者单位】：天津医科大学口腔医院;四川大学华西口腔医院;
【基金】：天津市自然科学基金重点项目(编号:16JCZDJC32800)
【分类号】：R782.11

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