EZH2和Ki-67蛋白在腺样囊性癌中的表达及其临床意义

发布时间：2018-06-22 11:10

本文选题：腺样囊性癌 + EZH　；参考：《中国肿瘤临床》2014年05期

【摘要】：目的:研究人涎腺腺样囊性癌组织中EZH2(enhancer of zeste homolog2)和Ki-67的表达及其相关性。方法:采用免疫组织化学染色法,检测石蜡包埋的42例涎腺腺样囊性癌(salivary adnoid cystic carcinoma,SACC)及5例正常涎腺组织中,多梳组蛋白EZH2和细胞周期蛋白Ki-67的表达水平,分析与临床病理特征之间的关系并探讨二者的相关性。结果:EZH2在腺样囊性癌组织中的表达显著高于正常涎腺组织(P0.05),EZH2表达阳性率66.67%(28/42),EZH2表达与肿瘤病理分型及临床分期相关,而与性别、年龄、发病部位不相关,而在5例正常涎腺组织中不表达。在Ki-67阳性的33例腺样囊性癌患者中,25例EZH2表达阳性,表达率75.76%(25/33),Ki-67阴性表达的9例中,3例EZH2表达阳性,表达率33.33%(3/9),两者比较差异有统计学意义(P0.05)。结论:EZH2在腺样囊性癌中表达增加且与肿瘤细胞的增殖密切相关,提示腺样囊性癌中EZH2通过其在细胞周期管理中的作用,参与肿瘤细胞的增殖过程。
[Abstract]:Aim: to study the expression and correlation of EZH2 (enhancer of zeste homolog2 and Ki-67 in human salivary adenoid cystic carcinoma. Methods: the expression of EZH2 and Ki-67 in 42 cases of salivary adenoid cystic carcinoma (salivary adnoid cystic carcinoma) and 5 cases of normal salivary gland were detected by immunohistochemical staining. To analyze the relationship with clinicopathological features and to explore the correlation between them. Results the expression of EZH2 in adenoid cystic carcinoma was significantly higher than that in normal salivary gland (P0.05). The positive rate of EZH2 expression in salivary gland was 66.67% (28 / 42). No expression was found in 5 normal salivary gland tissues. Among 33 cases of adenoid cystic carcinoma with Ki-67 positive, 25 cases (75.76%) were positive for EZH2, and 3 cases (33.33%) were positive for EZH2 in 9 cases with negative expression of Ki-67 (P0.05). Conclusion the increased expression of EZH2 in adenoid cystic carcinoma is closely related to the proliferation of tumor cells, suggesting that EZH2 is involved in the proliferation process of adenoid cystic carcinoma through its role in cell cycle management.
【作者单位】：天津医科大学口腔医院口腔颌面外科;天津医科大学口腔医院病理科;
【分类号】：R739.8

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