富血小板血浆修复牙周骨缺损的临床疗效

发布时间：2018-07-03 04:13

本文选题：富血小板血浆(PRP) + 羟基磷灰石(HA)　；参考：《牙体牙髓牙周病学杂志》2014年07期

【摘要】：目的:比较富血小板血浆(PRP)和羟基磷灰石(HA)联合或单独应用HA对中、重度慢性牙周炎患者牙周骨缺损修复的疗效。方法:选择中、重度慢性牙周炎患者20例共20个骨缺损的患牙,随机分为2组,HA/PRP组于骨缺损区同时植入PRP与HA,HA组单独植入HA。术后3、6个月时观察牙龈退缩(GR)、探诊深度(PD)、临床附着水平(CAL)、牙周再附着的变化,并评估骨缺损高度和骨密度的改变,以平均光密度值变化(MOD)作为参考。结果:术后3、6个月相比两组的GR、PD、CAL无显著差异。牙周再附着方面,HA/PRP组术后3个月时显著优于HA组(P0.05),6个月时两组无统计学差异(P0.05)。术后3、6个月时HA/PRP组MOD值均明显高于HA组(P0.05)。结论:HA、HA/PRP均为治疗牙周骨缺损的有效方法;PRP对牙周骨缺损修复有一定的促进作用,并在术后3个月即可达到相对稳定的水平。
[Abstract]:Objective: to compare the efficacy of platelet rich plasma (PRP) and hydroxyapatite (HA) in the repair of periodontal bone defects in patients with moderate or severe chronic periodontitis. Methods: twenty patients with 20 bone defects were randomly divided into two groups: Ha-HA group and Ha-HA group in which PRP and HA were implanted simultaneously in the bone defect area. The changes of gingival retraction (gr), probing depth (PD), clinical attachment level (CAL), periodontal reattachment and bone defect height and bone mineral density (BMD) were observed 3 and 6 months after operation. The mean optical density (MOD) was used as a reference. Results: there was no significant difference in GRN PD-CAL between the two groups 3 and 6 months after operation. The periodontal reattachment in HA / PRP group was significantly better than that in HA group at 3 months (P0.05), but there was no significant difference between the two groups at 6 months (P0.05). At 3 and 6 months after operation, the value of MOD in HA / PRP group was significantly higher than that in HA group (P 0.05). Conclusion both of the two methods are effective in the treatment of periodontal bone defect. PRP can promote the repair of periodontal bone defect and can reach a relatively stable level 3 months after operation.
【作者单位】：南京医科大学口腔医学研究所;南京医科大学附属口腔医院牙周科;南京医科大学附属口腔医院检验科;
【基金】：江苏高校优势学科建设工程资助项目(2014-37) 2011年度高校科研成果产业化推进项目
【分类号】：R781.4

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