单磷酸阿糖腺苷注射剂联合溶菌酶肠溶片治疗小儿疱疹性口腔炎的临床研究

发布时间：2018-07-03 16:30

本文选题：单磷酸阿糖腺苷 + 溶菌酶肠溶片　；参考：《中国临床药理学杂志》2017年14期

【摘要】：目的观察单磷酸阿糖腺苷注射剂联合溶菌酶肠溶片治疗小儿疱疹性口腔炎的临床疗效及安全性。方法将54例疱疹性口腔炎患儿随机分为对照组27例和试验组27例。对照组予以利巴韦林10 mg·kg~(-1),qd,静脉滴注;试验组予以单磷酸阿糖腺苷5 mg·kg~(-1),qd,静脉滴注+溶菌酶肠溶片20 mg,tid,口服。2组患儿均治疗5 d。比较2组患儿的临床疗效、血清肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、白细胞介素-10(IL-10)水平,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为96.29%(26/27例)和77.78%(21/27例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的TNF-α分别为(2.21±0.29)和(4.18±0.47)μg·L~(-1),CRP分别为(7.85±1.12)和(12.57±1.43)mg·L~(-1),IL-10分别为(158.56±17.49)和(120.68±12.32)ng·L~(-1),差异均有统计学意义(均P0.05)。试验组发生的药物不良反应以恶心为主,对照组发生的药物不良反应以恶心和注射部位疼痛为主,且试验组和对照组的药物不良反应发生率分别为3.70%和7.41%,差异无统计学意义(P0.05)。结论单磷酸阿糖腺苷注射剂联合溶菌酶肠溶片治疗小儿疱疹性口腔炎的临床疗效确切,其能够显著降低患儿的血清TNF-α、CRP水平,促进IL~(-1)0表达,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the efficacy and safety of adenosine arabate monophosphate injection combined with lysozyme enteric-coated tablets in the treatment of herpes stomatitis in children. Methods 54 children with herpes stomatitis were randomly divided into control group (n = 27) and experimental group (n = 27). The control group was given ribavirin 10 mg kg ~ (-1) by intravenous drip, and the test group was given 5 mg kg ~ (-1) adenosine monophosphate and 20 mg / kg lysozyme enteric coated tablets for 5 days. The clinical efficacy, serum levels of TNF- 伪 C-reactive protein (CRP), interleukin-10 (IL-10) and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 96.29% (26 / 27 cases) and 77.78% (21 / 27 cases), respectively. The difference was statistically significant (P0.05). After treatment, TNF- 伪 was (2.21 卤0.29) 渭 g / L ~ (-1) and (4.18 卤0.47) 渭 g / L ~ (-1) CRP in experimental group and control group, respectively (7.85 卤1.12) and (12.57 卤1.43) mg / L ~ (-1) IL-10 were (158.56 卤17.49) and (120.68 卤12.32) ng / L ~ (-1), respectively (P 0.05). The adverse drug reactions in the trial group were mainly nausea, the adverse drug reactions in the control group were mainly nausea and injection site pain, and the incidence of adverse drug reactions in the test group and the control group were 3.70% and 7.41%, respectively. There was no significant difference between the two groups (P0.05). Conclusion adenosine monophosphate injection combined with lysozyme enteric-coated tablets is effective in the treatment of herpes stomatitis in children. It can significantly reduce serum TNF- 伪 -CRP level, promote IL-1 0 expression, and do not increase the incidence of adverse drug reactions in children with herpes stomatitis.
【作者单位】：嘉兴市第二医院口腔科;
【基金】：国家医学教育发展中心医学研究课题基金资助项目(2010-37-03-016)
【分类号】：R781.5

【参考文献】