P16蛋白在口咽癌和口腔癌中的表达及临床意义

发布时间：2018-07-05 18:59

本文选题：口咽鳞癌(OPSCC) + 口腔鳞癌(OSCC)　；参考：《实用口腔医学杂志》2017年02期

【摘要】：目的:分析口咽癌和口腔癌中P16蛋白表达情况及临床意义。方法:采用免疫组织化学染色法检测70例口咽癌和60例口腔癌中P16蛋白的表达情况,分析其与患者临床病理学指标的相关性及临床意义。结果:口咽癌中P16蛋白的阳性率为22.9%(16/70),与P16阴性组相比,患者的年龄、吸烟、病理分化、N分期和TNM临床分期具有统计学意义(P0.05);口腔癌中P16蛋白的阳性率为8.3%(5/60),与P16阴性组相比,病理分化和TNM临床分期有统计学意义(P0.05)。结论:口咽癌中P16蛋白阳性率明显高于口腔癌,HPV感染是口咽癌和口腔癌不可忽视的诱发因素。
[Abstract]:Objective: to analyze the expression and clinical significance of P 16 protein in oropharyngeal carcinoma and oral carcinoma. Methods: the expression of P16 protein was detected by immunohistochemistry in 70 cases of oropharyngeal carcinoma and 60 cases of oral carcinoma. The correlation between P16 protein and clinicopathological indexes and its clinical significance were analyzed. Results: the positive rate of P16 protein in oropharyngeal carcinoma was 22. 9% (16 / 70). Compared with P16 negative group, the patients' age, smoking, pathological differentiation, N stage and TNM clinical stage were statistically significant (P0.05), the positive rate of P16 protein in oral carcinoma was 8. 3% (5 / 60), compared with P16 negative group, the positive rate of P16 protein in oral carcinoma was 8. 3% (5 / 60), compared with that in P16 negative group. Pathological differentiation and TNM clinical staging were statistically significant (P0.05). Conclusion: the positive rate of P16 protein in oropharyngeal carcinoma is significantly higher than that in oral carcinoma.
【作者单位】：军事口腔医学国家重点实验室口腔疾病国家临床医学研究中心陕西省口腔疾病临床医学研究中心第四军医大学口腔医院颌面外科;军事口腔医学国家重点实验室口腔疾病国家临床医学研究中心陕西省口腔疾病临床医学研究中心第四军医大学口腔生物学教研室;军事口腔医学国家重点实验室口腔疾病国家临床医学研究中心陕西省口腔疾病临床医学研究中心第四军医大学口腔医院麻醉科;军事口腔医学国家重点实验室口腔疾病国家临床医学研究中心陕西省口腔疾病临床医学研究中心第四军医大学组织病理学教研室;
【分类号】：R739.8

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