白细胞介素-10基因型与墨玉县维吾尔族成人慢性牙周炎易患性的相关性研究

发布时间：2018-07-09 21:59

本文选题：白细胞介素- + 慢性牙周炎　；参考：《华西口腔医学杂志》2017年05期

【摘要】：目的探讨白细胞介素-10(IL-10)基因-597(C/A)位点单核苷酸多态性与新疆维吾尔自治区墨玉县维吾尔族成人慢性牙周炎(CP)之间的相关性。方法随机选取2013年4—5月本课题组对新疆墨玉县维吾尔族成人进行的口腔健康流行病学调查资料及采集的颊黏膜拭子样本共300例,根据纳入排除标准将其分为健康对照组、轻度CP组和中重度CP组,每组各100例。采用四引物等位基因特异性聚合酶链反应扩增法检测受试者IL-10-597位点基因型和等位基因的分布。采用卡方检验、有序多分类Logistic回归等方法进行统计学分析。结果 IL-10-597基因型及等位基因频率在健康对照组、轻度CP、中重度CP组分布的差异均无统计学意义(P0.05);抽取样本人群的年龄与CP具有相关性,55~65岁人群患CP的风险是低于35岁人群的25倍(OR=25.56,P0.001)。结论 IL-10-597(C/A)位点单核苷酸多态性与维吾尔族成人CP的发病风险无明显相关性。
[Abstract]:Objective to investigate the relationship between the single nucleotide polymorphism of interleukin-10 (IL-10) -597 (C / A) locus and chronic periodontitis (CP) in Uygur adults in Moyu County, Xinjiang Uygur Autonomous region. Methods A total of 300 oral health epidemiological data and buccal mucosal swabs from Uygur adults in Moyu County, Xinjiang, from April to May 2013 were randomly selected and divided into healthy control group according to exclusion criteria. There were 100 cases in each group in mild CP group and moderate and severe CP group. Four primer specific polymerase chain reaction (PCR) was used to detect the genotype and allele distribution of IL-10-597 locus. Chi-square test and ordered multiple logistic regression were used for statistical analysis. Results IL-10-597 genotype and allele frequency were detected in healthy controls. There was no significant difference in the distribution of CP between mild CPand moderate and severe CP groups (P0.05), and the risk of CP was 25 times lower than that of 35 years old (OR 25.56 P0.001). Conclusion the single nucleotide polymorphism of IL-10-597 (C / A) is not associated with the risk of CP in Uygur adults.
【作者单位】：新疆医科大学第一附属医院牙体牙髓病科;
【基金】：新疆维吾尔自治区自然科学基金(2014211C065)~~
【分类号】：R781.42

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