种植体周围龈沟液中SOD、GP-x、MDA水平的初步研究
发布时间：2018-07-27 14:36
【摘要】：种植义齿修复在临床上运用越来越广泛，然而种植体并发症会降低种植体的成功率，导致种植体的最终失败，其中种植体周围炎是种植体最常见的并发症之一，，如何预防和早期诊断种植体周围炎是目前亟待解决的问题。大量研究认为牙周炎的发生与氧化应激反应相关，种植体周围炎和牙周炎有着相似的病因及临床症状，因此，研究种植体周围炎的发生与氧化应激是否存在一定相关性对于临床上早期诊断和治疗种植体周围炎都有着重要意义。 钴铬合金烤瓷是临床上最常见的冠修复材料之一，但一些研究指出烤瓷熔附金属全冠的金属基底会游离出金属离子，对牙周健康造成一定影响，氧化锆全瓷因其良好的美观性，舒适性和生物相容性，逐渐成为临床上常用的口腔修复材料，但因为价格较高限制了患者的选择。因此，我们拟比较两种冠修复材料对种植体周围组织的影响，为临床上如何选择种植体上部修复材料提供参考依据。 目的： 1.通过比较种植体和天然牙龈沟液的量、牙周临床指标及龈沟液中SOD、GP-x、MDA、IL-1β水平，探讨种植体周围组织的健康状况与局部氧化应激的关系，为如何预防、早期诊断和治疗种植体周围炎提供理论基础。 2.通过检测钴铬合金烤瓷全冠和氧化锆全瓷冠修复种植体上部结构后的龈沟液的量、牙周临床指标及龈沟液中SOD、GP-x、MDA、IL-1β水平，探讨这两种冠修复材料对种植体周围组织的影响，为临床上种植体上部结构全冠修复材料的选择提供一定的理论依据。 方法： 1.纳入96位患者，种植体修复牙位121个，天然牙牙位121个。分组：分为健康种植体组（98例）、种植体周围黏膜炎组（23例）和健康天然牙对照组（121例）；对患者的菌斑指数、龈沟出血指数、探诊深度、龈沟液的量及龈沟液中SOD、GP-x、MDA、IL-1β水平进行检测。龈沟液量的检测采用吸潮纸尖称重法；SOD、GP-x、MDA、IL-1β水平检测运用双抗体夹心ELISA方法。 2.纳入96位患者，其中有121个种植体牙位（健康的种植体98例，种植体周围黏膜炎组23例）。其中钴铬合金金属烤瓷全冠修复69个种植体牙位，氧化锆全瓷冠修复52个种植体牙位。分组：A组为钴铬合金烤瓷全冠修复后种植体周健康者（56例）；B组为氧化锆全瓷冠修复后种植体周健康者（42例）；C组为钴铬合金烤瓷全冠修复后种植体周围黏膜炎者（13例）；D组为氧化锆全瓷冠修复后种植体周围黏膜炎者（10例）。对患者的菌斑指数、龈沟出血指数、探诊深度、龈沟液的量及龈沟液中SOD、GP-x、MDA、IL-1β水平进行检测。龈沟液量的检测采用吸潮纸尖称重法，SOD、GP-x、MDA、IL-1β水平检测运用双抗体夹心ELISA方法。 结果： 1.健康种植体与健康天然牙的GCF的量、PLI、SBI、PD指标的比较，差异无统计学意义（P＞0.05）。 2.健康种植体组SOD、GP-x、MDA、IL-1β水平稍高于对照组，差异无统计学意义（P＞0.05）。 3.种植体周围黏膜炎组GCF的量及PLI、SBI、PD指标、MDA、IL-1β水平均高于对照组和健康种植体组，SOD、GP-x水平低于对照组和健康种植体组，差异具有统计学意义（P＜0.05或P＜0.01）。 4.A组与B组、C组与D组之间GCF的量及PLI、SBI、PD指标、SOD、GP-x、MDA、IL-lβ水平的比较，差异无统计学意义（P＞0.05）。 5.A组和C组、B组和D组间GCF的量及PLI、SBI、PD指标、SOD、GP-x、MDA、IL-lβ水平的比较，GCF的量及PLI、SBI、PD指标、IL-lβ、MDA水平A组低于C组，B组低于D组；SOD、GP-x水平A组高于C组，B组高于D组，差异具有统计学意义（P＜0.01）。 结论： 1.种植体植入后种植体周局部微环境存在轻度的氧化应激反应。 2.种植体周围黏膜炎的发生与局部的氧化应激反应具有一定相关性，但是否存在因果关系还需进一步研究证实。 3.种植体上部结构两种全冠修复材料与种植体周围黏膜炎的发病无明显相关性。
[Abstract]:Implant prosthesis is becoming more and more widely used in clinical practice. However, implant complications will reduce the success rate of implants and lead to the final failure of implants. The periimplant inflammation is one of the most common complications of implant. How to prevent and early diagnosis of periimplant inflammation is a problem to be solved urgently. The occurrence of periodontitis is associated with oxidative stress. Periodermatitis and periodontitis have similar causes and clinical symptoms. Therefore, the study of whether there is a certain correlation between the occurrence of peri implant inflammation and oxidative stress is of great significance in the early diagnosis and treatment of periimplant inflammation.
Cobalt chromium alloy porcelain is one of the most common restorative materials in the clinic. However, some studies have pointed out that the metal substrate of the metal full crown of the porcelain fused to metal ions can be dissociated from metal ions and has a certain influence on the periodontal health. The zirconia all porcelain has gradually become a commonly used dental restorative material because of its good beauty, comfort and biocompatibility. But because the price is high, the patient's choice is limited. Therefore, we should compare the effect of two kinds of crown restorations on the tissue around the implant, and provide a reference for how to choose the upper prosthesis of the implant.
Objective:
1. by comparing the amount of implant and natural gingival crevicular fluid, periodontal clinical indicators and SOD, GP-x, MDA, and IL-1 beta levels in gingival crevicular fluid, the relationship between the health of the tissue around the implant and the local oxidative stress was explored to provide a theoretical basis for the prevention and early diagnosis and treatment of periimplant inflammation.
2. by detecting the amount of gingival crevicular fluid, periodontal clinical indexes and SOD, GP-x, MDA, IL-1 beta levels in gingival crevicular fluid, the effects of the two kinds of crown restorations on the surrounding tissue of the implant were investigated by detecting the total crown of cobalt chromium alloy porcelain fused to the superstructure of the implant and the effect of the two kinds of crown restorations on the tissue around the implant. A certain theoretical basis.
Method:
1. were included in 96 patients, 121 dental implants and 121 dental teeth. Groups were divided into healthy implant group (98 cases), periimplant mucositis group (23 cases) and healthy natural tooth control group (121 cases). The plaque index, gingival gingival bleeding index, depth of gingival crevicular fluid, SOD, GP-x, MDA, IL-1 beta in gingival crevicular fluid of the patients were measured. The detection of gingival crevicular fluid was performed by the method of weighing the moisture absorbing paper tip. The SOD, GP-x, MDA and IL-1 beta levels were detected by the double antibody sandwich ELISA method.
2. of the 96 patients were treated with 121 dental implants (98 healthy implants and 23 cases of periimplant mucositis), of which 69 implant teeth were repaired with cobalt chromium alloy metal crown, and 52 dental implants were repaired with zirconia full porcelain crown. Group A was a healthy person (56) with CO Cr alloy porcelain crown restoration (56 cases); B The group was 42 cases of periodontal health after the restoration of zirconia full porcelain crown (42 cases), and the group of 13 cases of periimplant mucositis after the restoration of cobalt chromium alloy porcelain fused to porcelain crown (13 cases), and the group of 10 cases of periimplant mucositis after the restoration of zirconium oxide fully porcelain crown (10 cases). The plaque index, gingival gingival bleeding index, the depth of the gingival crevicular fluid and the SO in the gingival crevicular fluid The levels of D, GP-x, MDA and IL-1 beta were detected. The gingival crevicular fluid volume was measured by the moisture absorption paper tip weighing method, SOD, GP-x, MDA and IL-1 beta levels detected by double antibody sandwich ELISA method.
Result:
1. there was no significant difference in GCF, PLI, SBI and PD between healthy implants and healthy natural teeth (P > 0.05).
2. the SOD, GP-x, MDA and IL-1 beta levels in the healthy implant group were slightly higher than those in the control group, and the difference was not statistically significant (P > 0.05).
3. the amount of GCF and the level of PLI, SBI, PD, MDA and IL-1 beta in the periimplant mucositis group were higher than those in the control group and the healthy implant group. The level of SOD and GP-x was lower than that of the control group and the healthy implants (P < 0.05 or P < 0.01).
There was no significant difference in GCF, PLI, SBI, PD, SOD, GP-x, MDA, and beta level between group 4.A and group B and group C (D > 0.05).
The amount of GCF between group 5.A and group C, group B and D, PLI, SBI, PD index, SOD, GP-x, MDA, and IL-l beta level are lower than those of the group.
Conclusion:
1. there was mild oxidative stress in the local microenvironment after implant placement.
2. there is a certain correlation between the occurrence of periprosthetic mucositis and local oxidative stress, but whether there is a causal relationship needs further studies to confirm.
3. there was no significant correlation between the two kinds of crown restoration materials and the incidence of perigraft mucositis.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R783.4
本文编号：2148135
[Abstract]:Implant prosthesis is becoming more and more widely used in clinical practice. However, implant complications will reduce the success rate of implants and lead to the final failure of implants. The periimplant inflammation is one of the most common complications of implant. How to prevent and early diagnosis of periimplant inflammation is a problem to be solved urgently. The occurrence of periodontitis is associated with oxidative stress. Periodermatitis and periodontitis have similar causes and clinical symptoms. Therefore, the study of whether there is a certain correlation between the occurrence of peri implant inflammation and oxidative stress is of great significance in the early diagnosis and treatment of periimplant inflammation.
Cobalt chromium alloy porcelain is one of the most common restorative materials in the clinic. However, some studies have pointed out that the metal substrate of the metal full crown of the porcelain fused to metal ions can be dissociated from metal ions and has a certain influence on the periodontal health. The zirconia all porcelain has gradually become a commonly used dental restorative material because of its good beauty, comfort and biocompatibility. But because the price is high, the patient's choice is limited. Therefore, we should compare the effect of two kinds of crown restorations on the tissue around the implant, and provide a reference for how to choose the upper prosthesis of the implant.
Objective:
1. by comparing the amount of implant and natural gingival crevicular fluid, periodontal clinical indicators and SOD, GP-x, MDA, and IL-1 beta levels in gingival crevicular fluid, the relationship between the health of the tissue around the implant and the local oxidative stress was explored to provide a theoretical basis for the prevention and early diagnosis and treatment of periimplant inflammation.
2. by detecting the amount of gingival crevicular fluid, periodontal clinical indexes and SOD, GP-x, MDA, IL-1 beta levels in gingival crevicular fluid, the effects of the two kinds of crown restorations on the surrounding tissue of the implant were investigated by detecting the total crown of cobalt chromium alloy porcelain fused to the superstructure of the implant and the effect of the two kinds of crown restorations on the tissue around the implant. A certain theoretical basis.
Method:
1. were included in 96 patients, 121 dental implants and 121 dental teeth. Groups were divided into healthy implant group (98 cases), periimplant mucositis group (23 cases) and healthy natural tooth control group (121 cases). The plaque index, gingival gingival bleeding index, depth of gingival crevicular fluid, SOD, GP-x, MDA, IL-1 beta in gingival crevicular fluid of the patients were measured. The detection of gingival crevicular fluid was performed by the method of weighing the moisture absorbing paper tip. The SOD, GP-x, MDA and IL-1 beta levels were detected by the double antibody sandwich ELISA method.
2. of the 96 patients were treated with 121 dental implants (98 healthy implants and 23 cases of periimplant mucositis), of which 69 implant teeth were repaired with cobalt chromium alloy metal crown, and 52 dental implants were repaired with zirconia full porcelain crown. Group A was a healthy person (56) with CO Cr alloy porcelain crown restoration (56 cases); B The group was 42 cases of periodontal health after the restoration of zirconia full porcelain crown (42 cases), and the group of 13 cases of periimplant mucositis after the restoration of cobalt chromium alloy porcelain fused to porcelain crown (13 cases), and the group of 10 cases of periimplant mucositis after the restoration of zirconium oxide fully porcelain crown (10 cases). The plaque index, gingival gingival bleeding index, the depth of the gingival crevicular fluid and the SO in the gingival crevicular fluid The levels of D, GP-x, MDA and IL-1 beta were detected. The gingival crevicular fluid volume was measured by the moisture absorption paper tip weighing method, SOD, GP-x, MDA and IL-1 beta levels detected by double antibody sandwich ELISA method.
Result:
1. there was no significant difference in GCF, PLI, SBI and PD between healthy implants and healthy natural teeth (P > 0.05).
2. the SOD, GP-x, MDA and IL-1 beta levels in the healthy implant group were slightly higher than those in the control group, and the difference was not statistically significant (P > 0.05).
3. the amount of GCF and the level of PLI, SBI, PD, MDA and IL-1 beta in the periimplant mucositis group were higher than those in the control group and the healthy implant group. The level of SOD and GP-x was lower than that of the control group and the healthy implants (P < 0.05 or P < 0.01).
There was no significant difference in GCF, PLI, SBI, PD, SOD, GP-x, MDA, and beta level between group 4.A and group B and group C (D > 0.05).
The amount of GCF between group 5.A and group C, group B and D, PLI, SBI, PD index, SOD, GP-x, MDA, and IL-l beta level are lower than those of the group.
Conclusion:
1. there was mild oxidative stress in the local microenvironment after implant placement.
2. there is a certain correlation between the occurrence of periprosthetic mucositis and local oxidative stress, but whether there is a causal relationship needs further studies to confirm.
3. there was no significant correlation between the two kinds of crown restoration materials and the incidence of perigraft mucositis.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R783.4
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