广西口腔颌面颈部原发性淋巴瘤EBV感染及其临床病理特征分析

发布时间：2018-07-31 09:05

【摘要】：目的探讨广西地区EBV感染与恶性淋巴瘤病理类型及发病的相关性。方法采用原位杂交技术检测81例口腔颌面颈部淋巴瘤的肿瘤组织中EBV编码的RNA(EBER),并分析其临床病理特征。结果 (1)EBER总阳性率为44.4%,霍奇金淋巴瘤占检出率的40%,非霍奇金淋巴瘤占检出率的45.1%,不同细胞来源的非霍奇金淋巴瘤依次占检出率的75%(T细胞淋巴瘤)、87.5%(NK/T细胞淋巴瘤)、2.9%(B细胞淋巴瘤),T细胞、NK/T细胞非霍奇金淋巴瘤EBER阳性率比B细胞非霍奇金淋巴瘤高,差异有统计学意义(P0.05)。(2)淋巴结内、外淋巴瘤EBER阳性率分别为17.9%、58.5%,二者比较差异有显著性(P0.05)。(3)50岁以上淋巴瘤患者EBER检出率(36.2%)低于50岁以下患者检出率(55.9%),差异无显著性(P0.05)。结论广西地区口腔颌面颈部淋巴瘤与EBV感染相关,其中以发生在淋巴结外弥散淋巴组织的NK/T细胞淋巴瘤最为显著。
[Abstract]:Objective to investigate the correlation between EBV infection and malignant lymphoma in Guangxi. Methods in situ hybridization technique was used to detect EBV encoded RNA (EBER), in 81 cases of oral and maxillofacial neck lymphoma and its clinicopathological features were analyzed. Results (1) the total positive rate of EBER was 44.4%. Hodgkin's lymphoma accounted for 40% of the detectable rate, non-Hodgkin 's lymphoma accounted for 45.1%, and non-Hodgkin 's lymphoma from different cell sources accounted for 75% (T cell lymphoma) or 87.5% (NK/T cell lymphoma) (B fine cell lymphoma). The EBER positive rate of T cell / T cell non Hodgkin's lymphoma was higher than that of B cell non Hodgkin's lymphoma. There was significant difference (P0.05). (2) in the positive rate of EBER in lymph nodes, the positive rate of EBER was 17.9% and 58.5%, respectively. There was significant difference between them (P0.05). (3) the detection rate of EBER in patients over 50 years old (36.2%) was lower than that in patients under 50 years old (55.9%), but there was no significant difference (P0.05). Conclusion EBV infection is associated with oral and maxillofacial neck lymphoma in Guangxi, especially NK/T cell lymphoma, which occurs in the diffuse lymphoid tissue of lymph nodes.
【作者单位】：右江民族医学院病理学教研室;右江民族医学院附属医院病理科;右江民族医学院附属西南医院病理科;右江民族医学院;
【基金】：国家自然科学基金专项基金(81341122) 广西卫生厅医药卫生计划课题(Z2013769) 广西高校科学技术研究项目(YB2014291) 百色市科学研究与技术开发计划(20130108)
【分类号】：R739.8

【相似文献】