复方黄芩含漱液与复方氯己定含漱液治疗慢性龈炎的疗效比较

发布时间：2018-08-04 20:50

【摘要】：目的:比较复方黄芩含漱液与复方氯己定含漱液治疗慢性牙龈炎的临床疗效及龈沟液中TNF-α的变化。方法:纳入慢性龈炎患者90例,按随机数表法将研究对象分为生理盐水(A)组、复方氯己定组(B)和复方黄芩组(C),每组30例,常规进行口腔洁治,分别在治疗前及治疗后1、2周和1个月记录菌斑指数、牙龈指数,检测龈沟液中TNF-α的含量。结果:4个时间点综合比较,3组患者菌斑指数有统计学差异(F=3.506,P=0.034),B组低于A、C组,而A组和C组无统计学差异(P=0.611);3组患者牙龈指数的差异有统计学意义(F=6.359,P=0.003),A组高于B、C组,而B和C组无统计学差异(P=0.911);3组患者龈沟液中TNF-α的浓度有统计学差异(F=3.780,P=0.027),A组高于B、C组,而B和C组无统计学差异(P=0.923)。结论:复方黄芩含漱液与复方氯己定含漱液缓解慢性牙龈炎炎症的效果相当。
[Abstract]:Objective: to compare the clinical efficacy of compound baicalin gargle and compound chlorhexidine gargle in the treatment of chronic gingivitis and the changes of TNF- 伪 in gingival crevicular fluid. Methods: 90 patients with chronic gingivitis were randomly divided into normal saline (A) group, compound chlorhexidine group (B) group and compound baicalin group (C), group. Plaque index, gingival index and TNF- 伪 in gingival crevicular fluid were measured before treatment and 1 week and 1 month after treatment, respectively. Results: there was significant difference in plaque index between the three groups (F = 3.506P 0.034). The gingival index of group B was lower than that of group A (P < 0.611), but there was no significant difference between group A and group C (P = 0.611). There was statistically significant difference in gingival index between group A and group C (F = 6.359P 0.003). Group A was significantly higher than group B (P < 0.05), but there was no significant difference in gingival index between group A and group C (P0. 611). The concentration of TNF- 伪 in gingival crevicular fluid was significantly higher in group A than that in group B and C (P = 0.911), but not in group B and C (P = 0.923). The concentration of TNF- 伪 in gingival crevicular fluid was significantly higher in group A than in group B (P = 0.911). Conclusion: compound Scutellaria baicalensis gargle and compound chlorhexidine gargle are effective in relieving chronic gingivitis.
【作者单位】：辽宁医学院附属第二医院;
【基金】：辽宁省自然科学基金(编号:2013022024)
【分类号】：R781.41

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