survivin在涎腺腺样囊性癌组织中表达及意义的Meta分析

发布时间：2018-08-31 08:05

【摘要】：目的:系统评价survivin的表达与涎腺腺样囊性癌(SACC)的临床病理特征之间的相关性。方法:计算机检索PubMed、Embase、Cochrane Library、web of science、OVID、Springerlink、中国学术期刊全文数据库(CNKI)、中国生物医学数据库(CBM)、万方、重庆维普等数据库。根据各研究间的异质性,采用固定或随机效应模型合并比值比(ORs)和相应的95%可信区间(CIs),分析survivin表达与SACC的关联。结果:共纳入10个病例对照研究,包括367例SACC患者及124例正常对照。Meta分析结果显示:survivin在SACC组织中高表达(OR=38.26,95%CI:17.37~84.29,P0.01),还与病理分型(OR=0.3,95%CI:0.17~0.55,P0.01)、临床分期(OR=0.23,95%CI:0.13~0.42,P0.01)以及淋巴结转移(OR=3.7,95%CI:1.82~7.56,P0.01)有关,差异有统计学意义。结论:survivin的表达可能与SACC临床病理特征相关,但受纳入文献数量及质量的影响,尚需累积大样本高质量的研究来进一步证实。
[Abstract]:Objective: to evaluate the correlation between the expression of survivin and the clinicopathological features of salivary adenoid cystic carcinoma (SACC). Methods: PubMed,Embase,Cochrane Library,web of science,OVID,Springerlink, Chinese academic journal full-text database (CNKI), China biomedical database (CBM), Wanfang Chongqing Weipu database were searched. According to the heterogeneity of each study, the correlation between survivin expression and SACC was analyzed by using fixed or random effect model combining ratio (ORs) and corresponding 95% confidence interval (CIs),. Results: a total of 10 case-control studies were conducted, including 367 patients with SACC and 124 normal controls. The results of meta-analysis showed that the high expression of OR=38.26,95%CI:17.37~84.29,P0.01 in SACC tissues was also associated with pathological classification (OR=0.3,95%CI:0.17~0.55,P0.01), clinical stage (OR=0.23,95%CI:0.13~0.42,P0.01) and lymph node metastasis (OR=3.7,95%CI:1.82~7.56,P0.01). The difference is statistically significant. Conclusion the expression of survivin may be related to the clinicopathological features of SACC, but it needs to be further confirmed by the quantity and quality of the literature involved.
【作者单位】：广西医科大学口腔医学院口腔颌面外科;北京大学口腔医学院;
【基金】：国家自然科学基金项目(No:81360404) 广西自然科学基金面上项目(No:2013GXNSFAA019231) 广西研究生教育创新计划项目(No:201010598RY10) 广西高等教育本科教学改革工程立项项目(No:2016JGA161)
【分类号】：R739.8

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