变形链球菌中的次级代谢产物及其在口腔生物被膜中的生态功能

发布时间：2018-09-12 18:59

【摘要】：口腔生物被膜是由数百种微生物构成的复杂微生物群体。变形链球菌作为其中的重要一员,被认为是引起龋病的主要病原菌。变形链球菌在牙齿表面以生物被膜形式生长的能力和它产酸耐酸的特点赋予其致龋性。不同的变形链球菌菌株之间保留了多样的次级代谢形式,这是与宿主长期共进化的结果。迄今为止,变形链球菌中报道的次级代谢产物包括10种细菌素(又称变链素)和一种聚酮/非核糖体肽类化合物。这些化合物多样的活性形式暗示了它们参与口腔生物被膜中跨种间和跨界间的相互作用。未来随着变形链球菌菌株数目的增加和更多菌株全基因组序列的完成,可以预见会有更多新颖活性次级代谢产物的出现。对变形链球菌次级代谢的研究不仅有助于治疗和预防口腔疾病,而且新颖活性次级代谢产物的发现对新药的研发也具有重要意义。
[Abstract]:Oral biofilm is a complex microbial community composed of hundreds of microorganisms. Streptococcus mutans, as an important member, is considered to be the main cause of caries. The ability of Streptococcus mutans to grow in the form of biofilm on the tooth surface and its acidogenic and acidogenic characteristics endow it with caries. Different strains of Streptococcus mutans retain a variety of secondary metabolic forms, which is the result of long-term co-evolution with the host. Up to now, the secondary metabolites reported in Streptococcus mutans include 10 bacteriocins and one polyketone / non-ribosomal peptide. The various active forms of these compounds imply that they are involved in interspecies and cross-boundary interactions in oral biofilms. With the increase of the number of Streptococcus mutans strains and the completion of the whole genome sequence of more strains, it can be predicted that there will be more new active secondary metabolites. The study of secondary metabolism of Streptococcus mutans is not only helpful for the treatment and prevention of oral diseases, but also of great significance for the development of new drugs.
【作者单位】：中国科学院微生物研究所微生物资源前期开发国家重点实验室;中国科学院大学;南京农业大学食品科技学院;
【基金】：国家自然科学基金(Nos.31570050,31522001)资助~~
【分类号】：R780.2

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